| 离心造粒包衣法制备洛索洛芬钠缓释微丸及体外释放度考察 |
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| 引用本文： | 陈云.离心造粒包衣法制备洛索洛芬钠缓释微丸及体外释放度考察[J].中国药师,2011,14(1):84-86. |
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| 作者姓名： | 陈云 |
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| 作者单位： | 雷州市人民医院,广东,雷州,524200 |
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| 摘 要： | 目的:制备洛索洛芬钠缓释微丸。方法:采用离心造粒包衣法制备洛索洛芬钠微丸。首先制备微晶纤维素空白母核和洛索洛芬钠含药素丸,并在此基础上进行丙烯酸树脂水分散体(Eudragit NE30D、Eudragit L30D-55)包衣,并对包衣微丸的释药特征进行探讨。结果:微晶纤维素(MCC)空白母核32～40目的收率约78.6%,含药素丸18～24目收率约88.2%,使用Eudragit NE30D和Eudragit L30D-55比例是20:1的包衣液,包衣增重10%。包衣干燥后,即得洛索洛芬钠缓释微丸,洛索洛芬钠缓释胶囊体外释药行为较好地符合Higuchi方程。结论:在优化的工艺条件下可制得表面光滑、圆整度高的洛索洛芬钠缓释微丸。
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| 关 键 词： | 洛索洛芬钠 缓释微丸 离心造粒包衣法 体外释放度 |
Preparation and Release Behavior in vitro of Loxoprofen Sodium Sustained-release Pellet Capsules by Centrifugal Granulator |
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| Chen Yun.Preparation and Release Behavior in vitro of Loxoprofen Sodium Sustained-release Pellet Capsules by Centrifugal Granulator[J].China Pharmacist,2011,14(1):84-86. |
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| Authors: | Chen Yun |
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| Institution: | Chen Yun(Leizhou People' s Hospital of Guangdong Province,Guangdong Leizhou 524200) |
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| Abstract: | Objective:To prepare loxoprofen sodium sustained-release pellet capsules.Method:Loxoprofen sodium sustained-release pellet capsules were prepared by powder layering method and coated with Eudragit NE30D and L30D-55 in a centrifugal granulator. The release behavior in vitro was also studied.Result:The yield of blank core pellets(32-40 mesh) was 78.6%with MCC as mateial and the yield of drug pellets(18-24 mesh) was 88.2%.The pellet weight was increased by 10%after coated by Eudragit NE30D and L30D-55(20:1).Th... |
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| Keywords: | Loxoprofen sodium Sustained-release pellets Centrifugal granulator Release rate in vitro |
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