| 离心造粒法制备托拉塞米缓释小丸胶囊及其释放度考察 |
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| 引用本文： | 谢燕萍.离心造粒法制备托拉塞米缓释小丸胶囊及其释放度考察[J].中国药师,2011,14(3):391-394. |
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| 作者姓名： | 谢燕萍 |
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| 作者单位： | 佛山市第一人民医院,广东佛山,528000 |
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| 摘 要： | 目的:制备托拉塞米缓释小丸胶囊。方法:采用离心造粒粉末层积法制备托拉塞米小丸,用丙烯酸树脂水分散体包衣,并对包衣小丸的释药特征进行探讨。结果:微晶纤维素(MCC)空白母核32～40目的收率约80.2%,含药素丸20～24目收率约87.6%,使用Eudragit NE30D包衣液,包衣增重10%。托拉塞米缓释胶囊体外释药行为较好地符合Higuchi方程。结论:在优化的工艺条件下可制得表面光滑、圆整度高的托拉塞米缓释小丸。
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| 关 键 词： | 托拉塞米 缓释小丸 离心造粒法 体外释放度 |
Studies on Preparation of Torasemide Sustained-Release Pellets Capsules by Centrifugal Granulator and Release Behavior in vitro |
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| Xie Yanping.Studies on Preparation of Torasemide Sustained-Release Pellets Capsules by Centrifugal Granulator and Release Behavior in vitro[J].China Pharmacist,2011,14(3):391-394. |
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| Authors: | Xie Yanping |
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| Institution: | Xie Yanping(Foshan First Hospital,Guangdong Foshan 528000,China) |
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| Abstract: | Objective:To prepare torasemide sustained-release pellets capsules.Method:Torasemide sustained-release pellets capsules were prepared by powder layering technique in a centrifugal granulation equipment and coated with Eudragit NE30D.The release mechanism was also studied in vitro.Result:The yield of core pellets prepared with MCC was 80.2%(32-40 mesh),and the yield of drug pellets was 87.6%(20-24 mesh).The coating fluid was Eudragit NE30D with coating weight gain of 10%.The preparation had good sustained re... |
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| Keywords: | Torasemide Sustained-release pellets Centrifugal granulator Release rate in vitro |
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