|
|||||
|
|
| 甲磺酸多沙唑嗪控释片的制备及体外释放度考察 | |
| 引用本文： | 朱春柳,沈琦,俞洪珍,高一萍. 甲磺酸多沙唑嗪控释片的制备及体外释放度考察[J]. 中国药师, 2011, 14(3): 324-327,331 |
| 作者姓名： | 朱春柳 沈琦 俞洪珍 高一萍 |
| 作者单位： | 1. 上海交通大学,上海,200030;中国科学院上海药物研究所 2. 上海交通大学,上海,200030 3. 中国科学院上海药物研究所 |
| 摘 要： | 目的：制备甲磺酸多沙唑嗪控释片，并对其体外释放度进行考察。方法：以乙基纤维素-聚乙二醇复合材料作为控释衣膜，制备双层渗透泵控释片。以自制片与市售参比制剂体外释放度的相似因子f2为评价指标，采用正交试验设计优化甲磺酸多沙唑嗪双层渗透泵控释片的处方；同时，采用扫描电镜考察了释药过程中复合衣膜表面微孔的形成情况。结果：优化处方呈现良好的零级释药特征（r=0．9996），在不同释放介质的释药行为基本一致。结论：甲磺酸多沙唑嗪控释片的体外释放特征与市售参比制剂相比具有良好的相似性（f2=76．75）。 |
| 关 键 词： | 甲磺酸多沙唑嗪 释放度 渗透泵 |
Preparation and in vitro Release of Doxazosin Mesylate Controlled-Release Tablets |
|
| Zhu Chunliu,Shen Qi,Yu Hongzhen,Gao Yiping. Preparation and in vitro Release of Doxazosin Mesylate Controlled-Release Tablets[J]. China Pharmacist, 2011, 14(3): 324-327,331 | |
| Authors: | Zhu Chunliu Shen Qi Yu Hongzhen Gao Yiping |
| Affiliation: | Zhu Chunliu~(1,2),Shen Qi~1,Yu Hongzhen~2,Gao Yiping~2(1.Shanghai Jiao Tong University,Shanghai 200030,2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences) |
| Abstract: | Objective:Doxazosin mesylate was selected as the model drug,and the ethylcellulose(EC)-polyethylene glycol(PEG) composite material was employed as the controlled film material to prepare bilayer osmotic pump tablets.Method:The formulation of core tablet was optimized by orthogonal design and the release profiles of various formulations were evaluated by similarity factor(f_2). Meanwhile,the micropore forming process of the controlled film during the dissolution was studied by SEM.Result:The dissolution of t... |
| Keywords: | Doxazosin mesylate Release in vitro Osmotic pump |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |