肺靶向多西紫杉醇壳聚糖微球的制备与工艺优化

目的：研制肺靶向多西紫杉醇壳聚糖微球，并对处方工艺进行筛选。方法：以壳聚糖为载体，采用乳化-化学交联法制备多西紫杉醇壳聚糖微球。在单因素考察的基础上，利用正交试验设计优化微球制备工艺，采用HPLC法测定微球的载药量与包封产率。结果：制得的微球显微观察形态圆整、表面光滑，无粘连；平均粒径为（8．63±0．27）μm，粒径7—12μm的微球平均占总数的83．5％，载药量为（25．01±1．80）％，包封产率为（85．54±2．21）％。结论：筛选的最佳处方工艺制备的微球粒径大小适宜，可满足肺靶向微球的要求；该制剂有可能成为临床肺部肿瘤治疗的一种靶向制剂。

Preparation and Optimization of Lung Targeting Chitosan Microspheres Containing Docetaxel

Objective:To optimize the formulation and preparation technique of lung targeting chitosan microspheres containing docetaxel(DTX).Method:Chitosan was used to prepare the microspheres loading with docetaxel by emulsion chemical crosslinking method.The formulation and preparation technique were optimized by orthogonal experiment accorded to the results of single-factor selecting experiment.The drug-loading rate and drug yield were determined by HPLC.Result:The docetaxel chitosan microspheres were regular and ...