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| 抗凋亡基因Bag-1在胃癌组织的表达及其临床意义 | |
| 引用本文： | 李莹,麻日虎,杨兵,李君. 抗凋亡基因Bag-1在胃癌组织的表达及其临床意义[J]. 中国药物与临床, 2011, 11(5): 522-523 |
| 作者姓名： | 李莹 麻日虎 杨兵 李君 |
| 作者单位： | 1. 深圳市龙岗区人民医院肿瘤内科,518172 2. 深圳市龙岗区中心医院消化内科 3. 深圳市龙岗区坪山人民医院肿瘤内科 |
| 基金项目： | 深圳市龙岗区科技计划支持项目 |
| 摘 要： | 目的探讨Bag-1蛋白在慢性胃炎和胃癌组织中的表达,及其与胃癌临床病理特征之间的关系。方法采用免疫组织化学法,分别检测46例慢性胃炎胃黏膜、50例胃癌组织标本中Bag-1蛋白的表达。结果 Bag-1蛋白在胃癌组织中表达阳性率显著高于慢性胃炎胃黏膜组织(P<0.05),并且与胃癌病理类型、性别、年龄、肿瘤直径无关,但Bag-1与病理分级、浸润深度、有无淋巴结转移及远处转移密切相关。结论 Bag-1基因与胃癌细胞的凋亡有关,其高表达在胃癌可以作为早期筛选的一项指标,对疾病的预后有重要意义。 |
| 关 键 词： | 胃肿瘤 免疫组织化学 胃炎 Bag-1 |
The expression of antiapoptotic gene Bag-1 in gastric cancer tissue and its clinical significance |
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| LI Ying,MA Ri-hu,YANG Bing,LI Jun. The expression of antiapoptotic gene Bag-1 in gastric cancer tissue and its clinical significance[J]. Chinese Remedies & Clinics, 2011, 11(5): 522-523 | |
| Authors: | LI Ying MA Ri-hu YANG Bing LI Jun |
| Affiliation: | . Department of oncology,Longgang District People′s Hospital of Shenzhen,Guangdong 518172,China |
| Abstract: | Objective To explore the expression of Bag-1 protein in chronic gastritis and gastric cancer tissue,and its correlation with clinical pathological features of gastric cancer. Methods Immunohistochemistry was used to detect the Bag-1 expression 46 mucous membrane specimens of chronic gastritis and 50 gastric cancer tissue specimens. Results The positive expression rate of Bag-1 protein in gastric cancer tissue was significantly higher than that in mucous membrane of chronic gastritis(P<0.05) . Furthermore,Ba... |
| Keywords: | Bag-1 |
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