| HPLC法测定盐酸异丙嗪注射液含量 |
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| 引用本文： | 谢强,宋新康,饶春意.HPLC法测定盐酸异丙嗪注射液含量[J].中国药品标准,2011,12(1):31-34. |
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| 作者姓名： | 谢强 宋新康 饶春意 |
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| 作者单位： | 1. 广东省梅州市药品检验所,广州,514071
2. 广东省药品检验所,广州,510180 |
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| 摘 要： | 目的:建立HPLC测定盐酸异丙嗪注射液的含量.方法:色谱条件为C18柱,流动相为水(用冰醋酸调节pH2.25±0.05)-甲醇(51:49),检测波长为254 nm.结果:盐酸异丙嗪在4-40ug.m-1范围内有良好的线性关系,y=115.767x+14.409 r=0.999 8(n=7),平均回收率为100.9%,...
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| 关 键 词： | 高效液相色语法 盐酸异丙嗪注封液 含量测定 |
Determination of Promethazine Hydrochloride Injection by HPLC |
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| Authors: | Xie Qiang Song Xin-kang and Rao Chun-yi |
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| Institution: | Xie Qiang1,Song Xin-kang1,Rao Chun-yi2(1.Meizhou Institute for Drug Control,Meizhou 514071,2.Guangdong Institute for Drug Control,Guangzhou 510180) |
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| Abstract: | Objective： To establish an HPLC method to determine Promethazine Hydrochloride. Method： The HPLC method was conducted on C18 column. The mobile phase was consisted of water （adjusted to pH2. 25 ±0. 05 by acetate） and methanol （51： 49）. The detective wavelength was 254 nm. Results ： There was a good linear relationship, within concentration range of 4 - 40 μg·m^-1 （ r = 0. 999 8, n = 7）. The average recovery was 100. 9% （RSD = 0. 6% n = 9）. Conclusion： The method is accurate, reliable with a good separation, and can be used for determination of Promethazine Hydrochloride Injection. |
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| Keywords: | HPLC Promethazine Hydrochloride Injection Determination |
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