| 水相中微波辐射下铜催化合成苯并噻唑衍生物 |
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| 引用本文： | 柯方,林晨,李鹏.水相中微波辐射下铜催化合成苯并噻唑衍生物[J].福建医科大学学报,2013(5):301-304. |
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| 作者姓名： | 柯方 林晨 李鹏 |
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| 作者单位： | 福建医科大学药学院药物化学系,福州350004 |
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| 基金项目： | 福建医科大学博士启动基金（2011BS006） |
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| 摘 要： | 目的：用微波辐射催化法在水相中合成苯并噻唑化合物。方法在150 W微波辐射条件下，以CuCl2和菲啰啉为催化剂，2-碘芳烃、芳醛和硫化钠在100℃水相中反应30 min得到目标苯并噻唑化合物。结果合成得到9个相应的苯并噻唑化合物，均通过1 H NMR、13C NMR和质谱确认结构，最高收率为94％。结论使用微波辐射法水相中合成目标产物，与传统方法相比，避免使用大量有机溶剂对环境造
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| 关 键 词： | 微波辅助合成 苯并噻唑 2-碘芳胺 芳醛 硫化钠 |
Copper-catalyzed Microwave-assisted Synthesis of Benzothiazoles Derivatives in Water |
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| KE Fang,LIN Chen,LI Peng.Copper-catalyzed Microwave-assisted Synthesis of Benzothiazoles Derivatives in Water[J].Journal of Fujian Medical University,2013(5):301-304. |
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| Authors: | KE Fang LIN Chen LI Peng |
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| Institution: | (Department of Pharmacy, Fujian Medical University, Fuzhou 350004, China) |
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| Abstract: | Objective Benzothiazoles were synthesized under microwave irradiation in water . Methods A variety of 2-iodoanilines and aldehydes could be reacted with sodium sulfide to give the desired corresponding products in high yields in 100 ℃ water for 30 min using copper catalysts under microwave ir-radiation . Results We have developed an efficient protocol for benzothiazoles ,9 target compounds can be synthesized in good to excellent yields up to 94% , and all of them were further characterized by 1 H NMR ,13C NMR and MS analysis . Conclusion Synthesis of target benzothiazoles compounds under microwave irradiation in water has an advantage of short reaction time and higher the yields compared to the conventional method . |
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| Keywords: | microwave-assisted synthesis Benzothiazoles 2-Iodoanilines Aldehydes Sodium sulfide |
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