Cognitive effects of lithium treatment in normal volunteers |
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| Authors: | Herbert Weingartner Matthew V. Rudorfer Markku Linnoila |
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| Affiliation: | (1) Laboratory of Psychology and Psychopathology, Unit on Cognitive Studies, National Institute of Mental Health, Building 10/4C116, 9000 Rockville Pike, 20205 Bethesda, MD, USA;(2) Laboratory of Clinical Science, National Institute of Mental Health, Building 10/2D46, 9000 Rockville Pike, 20205 Bethesda, MD, USA;(3) DICBR Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Building 10/3B-23, 9000 Rockville Pike, 20205 Bethesda, MD, USA |
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| Abstract: | Patients taking lithium often report difficulties in concentration, memory, learning, and attention and many of these complaints are verified on psychometric testing. Laboratory tests of cognitive functions in healthy volunteers on chronic lithium demonstrate that disruptions in memory-learning processes are apparent at the time of memory retrieval. Subjects, following chronic lithium treatment, produce more errors of commission in remembering previously occurring events while errors of omission appear to be unaffected. These effects are different from those produced by other psychoactive drugs that can also selectively alter and disrupt cognitive processes. |
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| Keywords: | Lithium Memory Cognition Normal volunteers |
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