氯沙坦与氢氯噻嗪复方制剂治疗老年轻中度高血压的临床观察

目的 比较氯沙坦/氢氯噻嗪复方制剂与氯沙坦单剂治疗老年轻中度高血压的疗效与经济学评价.方法 分为导入期2周和治疗期8周.共入选99例轻中度原发性高血压患者,随机分为两组:复方制剂组50例,单剂组49例;分别给予氯沙坦50 mg/氢氯噻嗪12.5 mg复方片荆和氯沙坦50 mg 片剂每日1次治疗;治疗4周末时血压控制不满意者坐位舒张压(SeDBP)≥85 mm Hg]随后4周分别增加氯沙坦50mg.结果 治疗2、4和8周后,复方制荆组与单剂组收缩压和舒张压均明显降低(均P<0.01);两组降压的总有效率相同,但是两组的显效率和有效率差异有统计学意义(均P<0.05).结论 复方制荆与单剂相比.能更快更显著降低收缩压和舒张压.对于需要两种或两种以上药物治疗的患者,复方制荆服药更方便,依从性更好,药物的效价比更好.

Clinical observation of Losartan and Hydrochlorothiazide compound preparation in patients with mild to moderate essential hypertension

Objective To compare therapeutic effect of Losartan and hydrochlorothiazed compound prepara- tion and Losartan in patients with mild to moderate hypertension and to conduct economical evaluation. Methods The trial began with 2 weeks lead-in period and followed by 8 weeks therapy. 99 cases of mild to moderate hyperten- sion were randomly divided into two groups: compound preparation group ( n = 50) and Losartan (n = 49). The pa- tients were given Losartan 50 mg/h ydrochlorothiazed 12.5 mg compound preparation and Losartan 50 mg ,once a day. If the SeDBP≥85 mm Hg at 4th week, Losartan was added to 50 rag. Results After two, four and eight weeks treatment, systolic blood pressure and diastolic decreased obviously (P < 0.01 for each) ;The overall effective rate of of antihypertension was the same in both groups, but the different ratio of availability and validity in two groups was significant ( P < 0.05 for each). Conclusion Losartan/hydrochlorothiazed compound preparation has significant advantage in improving both systolic and diastolic pressure compared with monotherapy of Losartan. In ad- dition, the patients receiving compound preparation are well tolerated, with higher compliance.