HOX11原癌基因的活化对儿童急性白血病预后的影响

目的:探讨HOX11原癌基因的活化对儿童急性白血病(acute leukemia,AL)预后的影响。方法:对HOX11原癌基因表达阳性和阴性的282例初治急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)及82例急性髓细胞白血病(acute mye-locytic leukemia,AML)患儿正规化疗后的治疗效应进行研究和分析。结果:在标危、中危、高危组ALL患儿的正规化疗中,HOX11原癌基因阳性表达患儿的复发或死亡率均明显高于表达阴性的患儿(分别为P<0.005,P<0.01,P<0.005);在AML患儿中,HOX11原癌基因阳性表达患儿的复发或死亡率虽与HOX11表达阴性患儿相比较差异无统计学意义P>0.05),但HOX11原癌基因活化的AML患儿临床化疗效果差。结论:HOX11原癌基因的活化可能影响AL的预后。

Effect of activation of HOX11 proto-oncogene on prognosis of acute leukemia in children

Objective:To study prognostic influence of HOX11 proto-oncogene activation on acute leukemia(AL) in children.Methods:The effect of regular chemotherapy was studied and analyzed in 282 children with primary acute lymphoblastic leukemia(ALL) and 82 children with acute myelocytic leukemia(AML) who had positive or negative HOX11 proto-oncogene expression.Results:During regular chemotherapy the relapse or mortality rate was significantly higher in HOX11-positive children with standard-risk(SR)-ALL,middle-risk(MR)-ALL,and high-risk(HR)-ALL compared with HOX11-negative children(P<0.005,P<0.01,P<0.005).For the children with AML,the difference in relapse or mortality rate was not significant between HOX11-positive and HOX11-negative patients(P>0.05),but HOX11-positive children achieved poorer clinical outcome than HOX11-negative children.Conclusion:The activation of the HOX11 proto-oncogene may influence the prognosis of AL in children.