| 短暂性脑缺血发作后大鼠海马区星形胶质细胞超微结构的改变 |
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| 引用本文： | 李军杰,宋旸,张致身. 短暂性脑缺血发作后大鼠海马区星形胶质细胞超微结构的改变[J]. 中华老年心脑血管病杂志, 2004, 6(1): 53-55 |
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| 作者姓名： | 李军杰 宋旸 张致身 |
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| 作者单位： | 1. 首都医科大学附属北京宣武医院神经内科,北京,100053
2. 首都医科大学解剖学教研室,北京,100054 |
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| 摘 要： | 目的 探讨短暂性脑缺血发作 (TIA)后大鼠星形胶质细胞的改变对缺血再灌注损伤的影响。方法 SD成年大鼠 12只 ,分成正常对照组、假手术组和实验组 ,采用 4 VO动物模型模拟SD大鼠短暂性脑缺血发作 ;应用透射电镜观察TIA后海马区星形胶质细胞超微结构变化。结果 实验组星形胶质细胞增生明显 ,胞突终端水肿 ,造成微血管管腔狭窄。结论 星形胶质细胞的胞突终足在短暂性脑缺血后发生水肿 ,机械性压迫微血管 ,从而成为缺血再灌注损伤过程中的重要因素之一
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| 关 键 词： | 脑缺血,短暂性 星形细胞 海马 显微镜检查,电子,扫描透射 |
| 文章编号： | 1009-0126(2004)01-0053-03 |
| 修稿时间： | 2002-09-30 |
Study on the ultrastructural changes of astroglia in rat hippocampus after transient ischemic attacks (TIA) |
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| LI Jun jie,SONG Yang,ZHANG Zhi shen. Study on the ultrastructural changes of astroglia in rat hippocampus after transient ischemic attacks (TIA)[J]. Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases, 2004, 6(1): 53-55 |
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| Authors: | LI Jun jie SONG Yang ZHANG Zhi shen |
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| Abstract: | Objective To study the effects of astrogliosis on reperfusion injury of brain in rats following transient ischemic attacks (TIA).Methods 4 VO SD rats model was adopted to simulate TIA. The changes of ultrastructural changes of astroglia in hippocampus areas were observed using transmission electron microscope.Results Astrogliosis in hippocampus of TIA group was obvious and manifested as edema of the end of astroglial plate which oppressed capillaries,resulting in obstruction of capillaries.Conclusions The edema of astroglial end plate and its mechanical oppression on capillaries play important role in the course of reperfusion injury after TIA in rat hippocampus. |
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| Keywords: | ischemic attack transient astrocytes hippocampus microscopy electron scanning transmission |
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