不同时间服用安博维对肾性高血压降压效果观察

目的观察不同时间给药对肾性高血压患者血压昼夜节律的影响。方法选择80例肾性高血压患者,随机均分为对照组、治疗组,对照组上午7时服用安博维150mg,治疗组晚上7时服用安博维150mg。给药8周后复测ABPM。比较两组血压昼夜节律的变化。结果两组治疗前24 h平均收缩压/舒张压、日间平均收缩压/舒张压、夜间平均收缩压/舒张压比较,差异无统计学意义（P〉0.05）;治疗8周后,2组平均收缩压/舒张压比较,差异无统计学意义（P〉0.05）。夜间平均收缩压/舒张压实验组较对照组下降明显（P〈0.05）;日间平均收缩压/舒张压对照组较实验组下降明显（P〈0.01）。两组治疗前夜间平均收缩压/舒张压下降率比较,差异无统计学意义（P〉0.05）;两组治疗前后自身比较,差异均有统计学意义（P〈0.05）;治疗后两组间比较,实验组比对照组血压下降率更高,差异有统计学意义（P〈0.05）。结论对于肾性高血压,安博维晚上服用,可以更好改变血压昼夜节律,从而达到保护靶器官的目的。

Effect of Irbesartan with deferent time on blood pressure in patients with renal hypertension

Objective To observe the effect of Irbesartan with defferent time on blood pressure in patient s with renal hypertension.Methods 80 patients with mild to moderate renal hypertension were randomly divided into two groups,including control group treated with 150mg Irbesartan at 7AM and treatment group treated with 150mg at 7PM.The change of 24h BP and blood pressure diurnal rhythm before treatment and 8 weeks later were compared.Results The 24h,day and night average SBP,DBP of two groups all significantly decreased（P0.01）.The night average SBP,DBP of treatment group significantly decreased compared with those of control group（P0.05）.Compared with control group,the effectiveness rates of diurnal rhythm of SBP and DBP of treatment group significantly increased（P0.01）.Conclusion Irbesartan can effectively decrease the blood pressure day-night rhythm in patients with renal hypertension by taken 150 mg at night.