Specific characteristics of cholinergic mechanisms of short-term memory in monkeys for different types of visual information: The effects of amizil |
| |
Authors: | K. N. Dudkin I. V. Chueva |
| |
Affiliation: | (1) Conscious Processes Modeling Group, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia |
| |
Abstract: | Experiments on rhesus macaques were used to study the relationship between the characteristics of delayed visual differentiation and stimulus properties in conditions of pharmacological treatment with the m-cholinoreceptor blocker amizil, with the aim of identifying how modification of cholinergic structures affects different types of information. Disturbances to short-term memory for all stimuli consisted of reductions in the duration of retention and increases in motor reaction times, but occurred at different doses of the blocker: amizil at a dose of 0.3 mg/kg significantly decreased the retention duration for information relating to spatial relationships. Delayed discrimination of shape, contrast, and size worsened after treatment with amizil at a dose of 0.45–0.50 mg/kg, while decreases in the duration of short-term storage of information relating to color started after amizil doses of 0.6–0.8 mg/kg. It is suggested that the short-term memory system includes a set of neurophysiological mechanisms in which the cholinergic structures are organized differently and whose specific properties result in differences in the characteristics of short-term storage of different types of visual information. Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 83, No. 10, pp. 16–23, October, 1997. |
| |
Keywords: | Rhesus macaque visual differentiation short-term memory cholinergic structures m-cholinoreceptor blocker |
本文献已被 PubMed SpringerLink 等数据库收录! |
|