大蒜对MNNG诱发实验性胃癌及癌前病变过程中血Tch,LDL,HDL的影响

在ＭＮＮＧ诱发大鼠胃腺癌及癌前病变的过程中，观察了血Ｔｃｈ、ＬＤＬ、ＨＤＬ的变化及大蒜对其的影响。结果显示：ＭＮＮＧ组血Ｔｃｈ与ＬＤＬ低于正常对照组，ＨＤＬ高于对照组，具有显著性差异，证明实验性胃癌及癌前病变伴有低Ｔｃｈ、ＬＤＬ血症和高ＨＤＬ血症。预防组和治疗组血Ｔｃｈ、ＬＤＬ、ＨＤＬ与对照组无显著性差异。与ＭＮＮＧ组比较，预防组Ｔｃｈ、ＬＤＬ略高，ＨＤＬ略低，但无显著性；治疗组Ｔｃｈ、ＬＤＬ高于ＭＮＮＧ组，有非常显著性意义，而ＨＤＬ相近，无显著性。提示大蒜对ＭＮＮＧ诱发实验性胃癌具有抑制与逆转作用。

Effect of Garlic on Serum Contents of Tch,LDL and HDL Observed in MNNG-induced Experimental Gastric Carcinoma and Precancerous Lesion

Effect of garlic on level of serum total cholesteral(Tch) low density lipoprotein(LDL)and high density Lipoprotein(HDL) in Wistar rats bearing gastric carcinoma and precancerous lesion induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)was studied.The results showed that rats of MNNG group(MG) showed lower levels than those of normal control group(NG) in terms of serum HDL,and that the difference was significant,a fact which indicated that experimental gastric carcinoma and precancerous lesion were associated with hypoTch-emia, hypo-LDL-emia and hyper-HDL-emia.Comparison between the prevention group(PG) and treatment group(TG) with NG,there was no significant difference. Rats of PG and TG were higher than MG In levels of serum Tch and LDL,the difference between PG and MG groups(P<0.01),but not between PG and MG groups.This suggested that garlic has inhibitory and reverse effect on MNNG-induced experimental gastric carcinoma and precancerous lesion.