| 实验性脑缺血组织cAMP、cGMP代谢水平变化的观察 |
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| 引用本文： | 姜明辉,刘多三,张昱,张伟. 实验性脑缺血组织cAMP、cGMP代谢水平变化的观察[J]. 吉林大学学报(医学版), 1989, 0(3) |
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| 作者姓名： | 姜明辉 刘多三 张昱 张伟 |
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| 作者单位： | 白求恩医科大学第一临床学院神经内科(姜明辉，刘多三，张昱)，白求恩医科大学第一临床学院神经内科(张伟) |
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| 摘 要： | 对犬脑颅底动脉结扎后引起实验性脑缺血不同时间的皮质环核苷酸(cAMP、cGMP)进行了观察。结果表明,cAMP在缺血早期(6h内)增高,而后逐渐下降。cGMP呈持续降低水平。脑缺血后环核苷酸(cAMP.CGMP)出现的这种变化反映出脑组织细胞代谢、介质传递紊乱状态。
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| 关 键 词： | 实验性脑缺血 环核苷酸 放射免疫测定 |
Observation on changes in concentration of cAMP and cGMP in experimental ischemic cerebral tissues |
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| Jiang Minghui,Liu Duosan,zhionyu Yu,Zhang wei. Observation on changes in concentration of cAMP and cGMP in experimental ischemic cerebral tissues[J]. Journal of Jilin University: Med Ed, 1989, 0(3) |
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| Authors: | Jiang Minghui Liu Duosan zhionyu Yu Zhang wei |
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| Abstract: | cAMP and cGMP metabolic levels in cerebral tissues were observed in experimental cerebral ischemia induced by clipping cerebral arteries in dogs. Tissue cyclic AMP content markedly increased within 6 h following occlusion of the arteries, however, it gradually decreased with longer period of ischemia. Tissue cyclic GMP concentration in ischemic cerebral tissues displayed a significant decrease. These results illustrated that disorders ensued in cerebral tissue metabolism and transmission of mediators following ischemic strokes. |
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| Keywords: | Experimental cerebral ischemia cAMP and cGMP in cerebral tissue Radioactive immunoassay |
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