2-Methoxyestradiol deficiency is strongly related to hypertension in early onset severe pre-eclampsia |
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| Institution: | 1. Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China;2. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200127, China;3. Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;4. Liggins Institute, The University of Auckland, Auckland 1142, New Zealand;1. Department of Mathematics, University of Mostaganem, Box 227, Mostaganem 27000, Algeria;2. Department of Mathematics, Faculty of Sciences, University of Oran, Box 1524, Oran 31000, Algeria;3. Dipartimento di Matematica e Informatica, Universit a di Catania, Viale Andrea Doria, 6, 95125 Catania, Italy;4. School of Mathematics and Computer Sciences, Gannan Normal University, Ganzhou 341000, China;1. School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea;2. Department of Nanobio Materials and Electronics, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea;3. Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093-0407, USA |
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| Abstract: | Objective2-Methoxyestradiol (2ME) deficiency leading to placental insufficiency has been related to pre-eclampsia (PE). Here we investigate whether 2ME is related to clinical profiles and vasoactive factors in early onset severe PE patients.Methods28 severe PE patients and 20 uncomplicated normal pregnant women, with gestational weeks between 24 and 32 weeks, were recruited. All cases and controls had singleton pregnancies and were matched for maternal age, parity, body mass index, and gestational weeks. Plasma levels of 2ME, estradiol (E2), soluble Fms-like tyrosine kinase-1 (sFLT-1), endothelin-1 (ET-1), nitric oxide (NO) were determined.ResultsPE patients had significant lower 2ME 906(422–1768) vs. 2032(1400–2910) pg/mL, P = 0.002], higher sFLT-1 5.55(3.24–11.22) vs. 3.13(2.17–5.36) ng/mL, P = 0.015] and higher NO 122.40(72.92–168.23) vs. 45.83(25.52–61.46) μmol/L, P = 0.0008] levels in their plasma than the controls. In the PE group, plasma 2ME level correlated negatively with systolic pressure (r = ?0.48, P = 0.012), diastolic pressure (r = ?0.52, P = 0.007) and mean arterial pressure (r = ?0.54, P = 0.005) even after controlling for maternal age; 2ME level did not correlate with proteinuria, plasma levels of E2, sFLT-1, ET-1 or NO. In the control group, plasma 2ME level did not correlate with any of the above clinical profiles or laboratory measurements.Conclusions2ME levels were markedly lower in early onset severe PE and they correlated inversely with blood pressure only in women with PE. Although we cannot tell whether lower 2ME level is the causation or the result of PE, our study provides clinical evidences that 2ME deficiency is strongly related to hypertension in early onset severe PE patients. |
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| Keywords: | Pre-eclampsia 2-Methoxyestradiol Estradiol Soluble Fms-like tyrosine kinase-1 Endothelin-1 Nitric oxide |
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