Bone mineral density in pediatric survivors of Hodgkin and non-Hodgkin lymphomas |
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| Institution: | 1. Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland;2. Department of Pediatrics and Developmental Disorders, Medical University of Bialystok, Bialystok, Poland;3. Student''s Scientific Society by the Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland;1. School of Applied Sciences, Cranfield University, United Kingdom;2. School of Computer Science and Electrical Engineering, University of Essex, United Kingdom;1. Service de pharmacologie clinique, centre antipoison et de toxicovigilance (CAPTV), hôpitaux Sud, hôpital Sainte-Marguerite, AP–HM, 270, boulevard Sainte-Marguerite, 13009 Marseille, France;2. Aix-Marseille université, 13284 Marseille, France;1. Department of Cardiology, Medical University of Bialystok, Bialystok, Poland;2. Department of Cardiac Surgery, Medical University of Bialystok, Bialystok, Poland;3. Department of Nephrology, Medical University of Bialystok, Bialystok, Poland;1. 2nd Department of Internal Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania;2. Medical Informatics and Biostatistics Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania;3. Biochemistry Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania |
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| Abstract: | PurposeTo assess skeletal mass in survivors of childhood Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL) 1–5 years after treatment, and to identify potential risk factors influencing bone mineral density (BMD).Patients/methodsThis cross-sectional study was conducted in a cohort of 43 survivors (HD = 31; NHL = 12); mean age: 16.21 ± 4.4. Total body bone mineral content (TBMC) and density (TBBMD), and lumbar spine density (LSBMD) were determined using dual-energy X-ray absorptiometry.ResultsThree of all 43 patients developed low BMD. No significant differences in height, weight, and/or BMD Z-scores were found between HD and NHL survivors, children who received and did not receive radiotherapy, and the groups with different chemotherapeutic blocks. No differences were noted between the Z-scores of BMC (mean ± SD: 0.31 ± 1.29 vs. ?0.089 ± 0.61, p = 0.165), TBBMD (mean ± SD: ?0.32 ± 1.21 vs. ?0.27 ± 0.91, p = 0.76), or the LSBMD (mean ± SD: ?0.183 ± 1.54 vs. ?0.17 ± 0.87, p = 0.637) in subgroups, in accordance with time after therapy (subgroup I < 2 years and subgroup II > 2 years after treatment). In HD survivors, age at diagnosis only affected the TBBMD Z-score (a decrease of 0.127 in total BMD Z-score per each year, R2 = 0.999, p < 0.001).ConclusionsChildhood lymphoma survivors demonstrate no significant deficits in bone mass and tend to maintain their BMD within the normal range when presenting during one to five years’ follow-up. However, this specific group requires longitudinal investigation to assess the pattern of peak bone mass achievement and the risk of future bone loss. |
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| Keywords: | Bone mineral density Non-Hodgkin lymphoma Hodgkin lymphoma Survivors Children |
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