Baseline diabetic knowledge after 5-day teaching program is an independent predictor of subclinical macroangiopathy in patients with type 1 diabetes (Poznan Prospective Study) |
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| Institution: | 1. School of Applied Sciences, Cranfield University, United Kingdom;2. School of Computer Science and Electrical Engineering, University of Essex, United Kingdom;1. Department of Cardiology, Medical University of Bialystok, Bialystok, Poland;2. Department of Cardiac Surgery, Medical University of Bialystok, Bialystok, Poland;3. Department of Nephrology, Medical University of Bialystok, Bialystok, Poland;1. I Department of Cardiology, Invasive Electrocardiology and Hypertension, Jagiellonian University Medical College, University, Krakow, Poland;2. Department of Invasive Cardiology, Electrotherapy and Angiology, Nowy Sacz Hospital, Nowy Sacz, Poland;1. Service de pharmacologie clinique, centre antipoison et de toxicovigilance (CAPTV), hôpitaux Sud, hôpital Sainte-Marguerite, AP–HM, 270, boulevard Sainte-Marguerite, 13009 Marseille, France;2. Aix-Marseille université, 13284 Marseille, France;1. Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA 16802, United States;2. Electrical and Computer Engineering Department, Universidad Del Turabo, Gurabo, PR 00778, United States;3. Department of Electrical Engineering, The Pennsylvania State University, University Park, PA 16802, United States;1. 2nd Department of Internal Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania;2. Medical Informatics and Biostatistics Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania;3. Biochemistry Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania |
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| Abstract: | PurposeThe cardiovascular diseases (CVD) are the leading cause of mortality in type 1 diabetes (DM1). Carotid intima-media thickness (IMT) has been approved as a marker of subclinical atherosclerosis. The aim of this prospective study was to evaluate the relationship between baseline diabetic knowledge after five-day teaching program and IMT in patients with (DM1) treated with intensive functional insulin therapy (IFIT) from the onset of the disease.Material/methodsThe analysis included 79 subjects aged 23.4 ± 5.1 years with newly diagnosed DM1, participating in Poznan Prospective Study (PoProStu). The patients attended a five-day structured training program in IFIT at diagnosis, followed by a test consisting of 20 questions. After follow-up period of 11 years we evaluated the presence of microangiopathy and subclinical macroangiopathy. IMT of the right common carotid artery was determined using high resolution ultrasonography and calculated automatically with the Carotid Analyzer for Research program.ResultsAfter 11-year follow-up median intima-media thickness was 560 (IQR: 520–630) μm. We found a negative correlation between diabetes knowledge at baseline and IMT at the end of follow-up (r = ?0.27, p = 0.017). In multivariate linear regression model baseline diabetic knowledge test result was associated with IMT at follow-up, independently from sex, age, smoking status, presence of hypertension and diabetic kidney disease (all at follow-up) and from mean follow-up LDL-cholesterol concentrations and HbA1c results (β = ?8, 95% CI ?16, ?1, p = 0.037).ConclusionsBaseline diabetic knowledge after 5-day teaching program is an independent predictor of subclinical macroangiopathy in patients with DM1. |
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| Keywords: | Type 1 diabetes Intima-media thickness Macroangiopathy Intensive functional insulin therapy Education |
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