Short-term response of metabolic hormones to coronary artery bypass surgery |
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| Institution: | 1. Heart Institute, Faculty of Medicine, University of Pécs, Pécs, Hungary;2. Institute of Public Health and Health Promotion, Faculty of Health Sciences, University of Pécs, Pécs, Hungary;3. Department of Cardiac Surgery, Zala County Hospital, Hungary;4. Klinik für Kinder und Jugendliche, University of Erlangen-Nürnberg, Nürnberg, Germany;1. Department of Anatomy, MTA-PTE PACAP “Lendulet” Research Team, University of Pecs, Pecs, Hungary;2. Department of Surgery, University of Pecs, Pecs, Hungary;3. Department of Biochemistry and Medical Chemistry, University of Pecs, Pecs, Hungary;4. Department of Surgical Research and Techniques, University of Pecs, Pecs, Hungary;1. 2nd Department of Coronary Artery Disease, Institute of Cardiology, Warsaw, Poland;2. Department of Arrhythmia, Institute of Cardiology, Warsaw, Poland;1. Daily Department, Hospital of Infectious Diseases, Warsaw, Poland;2. Department of Immunopathology of Infectious and Parasitic Diseases, Warsaw Medical University, Warsaw, Poland;3. Department of Molecular Diagnostics, Hospital of Infectious Diseases, Warsaw, Poland;4. Department of Pathomorphology, Medical Center for Postgraduate Education, Warsaw, Poland;5. Department of Pathomorphology, National Institute of Hygiene, Warsaw, Poland;6. Department of Infectious Diseases for Adults, Warsaw Medical University, Warsaw, Poland;1. Department of Medical Physiology, Health Care Faculty, Jagiellonian University Collegium Medicum, Krakow, Poland;2. Department of Cell Morphology Medical Faculty, Jagiellonian University Collegium Medicum, Krakow, Poland |
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| Abstract: | PurposeTo explore the response pattern of plasma adipokine and ghrelin levels to coronary artery bypass graft (CABG) surgery in patients with (on-pump) and without (off-pump) cardiopulmonary bypass (CPB).Material/methodsSixteen consecutive patients (age: 62 ± 10 years, male: 10) with obstructive coronary artery disease (CAD) who underwent elective CABG surgery with CPB and intraoperative GIK infusion were selected for on-pump group and 19 CAD patients (age: 63 ± 10 years, male: 16) were included in the off-pump group. Blood samples were taken before, during and after surgery. Intraoperative samples were withdrawn simultaneously for peripheral vein and sinus coronarius (SC). Plasma adipokine concentrations were measured by ELISA, those of ghrelin by RIA kits.ResultsIn response to surgical intervention there was an early, transient fall in plasma levels of adiponectin (p < 0.0001) and resistin (p = 0.002) followed by an increase to approach their initial values. Plasma ghrelin also increased (p = 0.045), this increase, however, was confined to the period of GIK supported CPB. Plasma insulin (p = 0.003) and resistin (p = 0.009) was significantly higher in the peripheral vein than in SC. The perioperative hormone profile of patients without CPB (off-pump) proved to be comparable to that of on-pump patients in spite of the insulin administration and greater oxidative and inflammatory stress.ConclusionsAdipose tissue-derived factors appear to mediate the metabolic and vascular changes that occur in patients with CABG surgery. Epicardial adipose tissue is unlikely to have major contribution to the development of CAD as adipokines are not elevated in SC independent of the mode of intervention. |
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| Keywords: | Coronary artery bypass graft Cardiopulmonary bypass Metabolic hormones |
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