Clinician Accessible Tools for GUI Computational Models of Transcranial Electrical Stimulation: BONSAI and SPHERES |
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Institution: | 1. Department of Clinical Neurophysiology, Georg-August-University, Göttingen, Germany;2. Department of Diagnostic and Interventional Radiology, University Clinics of Tübingen, Germany;3. Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark;4. Biomedical Engineering Section, Technical University of Denmark, Kgs. Lyngby, Denmark;5. Max-Planck Institute for Biological Cybernetics, Tübingen, Germany;6. Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA;7. Center for the Developing Brain, Child Mind Institute, New York, NY 10022, USA |
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Abstract: | Computational models of brain current flow during transcranial electrical stimulation (tES), including transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), are increasingly used to understand and optimize clinical trials. We propose that broad dissemination requires a simple graphical user interface (GUI) software that allows users to explore and design montages in real-time, based on their own clinical/experimental experience and objectives. We introduce two complimentary open-source platforms for this purpose: BONSAI and SPHERES. BONSAI is a web (cloud) based application (available at neuralengr.com/bonsai) that can be accessed through any flash-supported browser interface. SPHERES (available at neuralengr.com/spheres) is a stand-alone GUI application that allow consideration of arbitrary montages on a concentric sphere model by leveraging an analytical solution. These open-source tES modeling platforms are designed go be upgraded and enhanced. Trade-offs between open-access approaches that balance ease of access, speed, and flexibility are discussed. |
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Keywords: | Transcranial electrical stimulation Transcranial direct current stimulation Transcranial alternating current stimulation Modeling Open access Dose |
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