Intravenous thrombolysis for acute ischemic stroke |
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Affiliation: | 1. Stroke unit, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France;2. Université Paris Descartes, Sorbonne Paris Cité, France;3. Inserm UMR S894, France |
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Abstract: | Intravenous thrombolysis (IVT) with alteplase remains the standard treatment for acute ischemic stroke. Although IVT can be started up to 4.5 hours after symptoms’ onset, it is all the more effective and safe when started early. It allows a 10% absolute reduction in the risk of handicap or death at 3 months, despite a 2–7% risk of symptomatic intracranial hemorrhage. Current research efforts involve firstly trying to treat a larger proportion of patients by overcoming some of the contraindications to IVT and secondly assessing combined or alternative treatments to achieve a higher early recanalization rate. |
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Keywords: | Stroke Ischemia Thrombolysis Interventional radiology Thrombectomy |
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