首页 | 本学科首页   官方微博 | 高级检索  
检索        


Targeting of White Matter Tracts with Transcranial Magnetic Stimulation
Institution:1. MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, MA, USA;2. Harvard Medical School, MA, USA;3. Department of Radiology, Stanford University, CA, USA;4. Brigham and Women''s Hospital, MA, USA;5. Department of Neurology, Boston Children''s Hospital, MA, USA;6. Harvard-MIT Division of Health Sciences and Technology, MA, USA;7. Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, MA, USA;1. Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany;2. TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München, Munich, Germany;3. Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany;4. Department of Clinical Neurophysiology, Kuopio University Hospital, POB 100, 70029 KYS, Kuopio, Finland;5. A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland;6. Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland;7. Department of Applied Physics, University of Eastern Finland, Kuopio, Finland;1. Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA;2. Behavioural Brain Sciences, School of Psychology, University of Birmingham, Birmingham, UK;1. Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland;2. BioMag Laboratory, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;3. Aalto TMS Laboratory, Aalto Neuroimaging, Aalto University, Espoo, Finland;4. Department of Psychiatry, University of Wisconsin, Madison, WI, USA;1. Section for Magnetic Resonance, Department of Health Technology, Technical University of Denmark, Kgs, Lyngby, Denmark;2. MagVenture A/S, Farum, Denmark;3. Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark;4. Department of Neurology, Copenhagen University Hospital Frederiksberg and Bispebjerg, Copenhagen, Denmark;5. Department for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark;6. Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs Lyngby, Denmark;1. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA;2. Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Espoo, Finland;3. Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK;4. Moment Technologies, LLC, Boston, MA 02129, USA;5. Department of Neurology, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA;1. Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands;2. 4Brain, Department of Head and Skin, Ghent University, Ghent, Belgium;3. Department of Neurology, Ghent University Hospital, Ghent, Belgium;4. Ghent Experimental Psychiatry Laboratory, Department of Head and Skin, Ghent University, Ghent, Belgium;5. Department of Psychiatry, University Hospital Brussels, Jette, Belgium;6. Center for Brain Circuit Therapeutics, Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusetts
Abstract:BackgroundTMS activations of white matter depend not only on the distance from the coil, but also on the orientation of the axons relative to the TMS-induced electric field, and especially on axonal bends that create strong local field gradient maxima. Therefore, tractography contains potentially useful information for TMS targeting.Objective/methodsHere, we utilized 1-mm resolution diffusion and structural T1-weighted MRI to construct large-scale tractography models, and localized TMS white matter activations in motor cortex using electromagnetic forward modeling in a boundary element model (BEM).ResultsAs expected, in sulcal walls, pyramidal cell axonal bends created preferred sites of activation that were not found in gyral crowns. The model agreed with the well-known coil orientation sensitivity of motor cortex, and also suggested unexpected activation distributions emerging from the E-field and tract configurations. We further propose a novel method for computing the optimal coil location and orientation to maximally stimulate a pre-determined axonal bundle.ConclusionsDiffusion MRI tractography with electromagnetic modeling may improve spatial specificity and efficacy of TMS.
Keywords:Transcranial magnetic stimulation  TMS  Diffusion MRI tractography  Electromagnetic modeling  Navigation  Coil orientation  DTI"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"diffusion tensor imaging  MRI"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"magnetic resonance imaging  TMS"}  {"#name":"keyword"  "$":{"id":"kwrd0065"}  "$$":[{"#name":"text"  "_":"transcranial magnetic stimulation
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号