Metallothionein immunoexpression in non-syndromic
and syndromic keratocystic odontogenic tumour |
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| Authors: | Aline-Cristina-Batista-Rodrigues Johann Patrícia-Carlos Caldeira Marcelo-Vidigal Caliari Ricardo-Santiago Gomez Maria-Cássia-Ferreira Aguiar Ricardo-Alves Mesquita |
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| Affiliation: | 1.DDS, PhD. Pontifícia Universidade Católica do Paraná, School of Health and Biosciences, Curitiba, PR, Brazil;2.DDS, PhD. DDS, PhD. DDS, PhD. DDS, PhD. Department of Oral Surgery and Oral Pathology, School of Dentistry, Universidade Federal de Minas Gerais;3.PhD Department of Pathology, Biological Sciences Institute, Universiade Federal de Minas Gerais |
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| Abstract: | BackgroundTo compare the metallothionein (MT) immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour (KOT), to correlate MT with cellular proliferation, and to evaluate the influence of inflammation in MT.Material and MethodsFourteen cases of KOT were submitted to immunohistochemistry for MT and Ki-67 analysis. The lesions were grouped according to their grade of inflammation, and statistical analysis was performed.ResultsMT was higher in non-syndromic KOT than in syndromic KOT (p<0.05). No statistical difference in Ki-67 could be identified; however, an inverse correlation was observed between MT and Ki-67 in both lesions. When analysing inflammation, non-syndromic KOT showed no differences in either MT or Ki-67.ConclusionsThe MT immunophenotype of syndromic KOT was different from non-syndromic KOT. MT might not be involved in the proliferation control of both KOT. MT and Ki-67 immunoexpressions proved to be unaffected by inflammation in non-syndromic KOT.Key words:Odontogenic tumours, basal cell nevus syndrome, metallothionein, Ki-67 Antigen, immunohistoche-mistry. |
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