Intestinal anti-inflammatory activity of the Serpylli herba extract in experimental models of rodent colitis |
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| Affiliation: | 1. CIBER-EHD, Department of Pharmacology, Institute for Bio-Health Research of Granada, Center for Biomedical Research, University of Granada, Granada, Spain;2. PhytoLab GmbH & Co. KG, Dutendorfer Strasse 5-7, 91487 Vestenbergsgreuth, Germany;3. Finzelberg GmbH & Co. KG, Koblenzer Strasse 48-56, 56626 Andernach, Germany;1. Department of Gastroenterology and Hepatology, Academic Medical Center, The Netherlands;2. Department of Surgery, Academic Medical Center, The Netherlands;3. Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, The Netherlands;4. Department of Gastroenterology and Hepatology, Onze Lieve Vrouwe Gasthuis, The Netherlands;5. Department of Gastroenterology and Hepatology, St Lucas Andreas Hospital, The Netherlands;6. Department of Gastroenterology and Hepatology, Medical Centre Alkmaar, The Netherlands;7. Department of Gastroenterology and Hepatology, Free University Medical Centre, The Netherlands;1. Dept Gastroenterology and Hepatology, Flinders Medical Centre, South Australia, Australia;2. IBD Service, Dept Gastroenterology and Hepatology and School of Medicine, University of Adelaide at Royal Adelaide Hospital, South Australia, Australia;3. Flinders University of South Australia, Australia;1. Gastroenterology, Lenox Hill Hospital, New York, NY, United States;2. New York University School of Medicine, United States;3. ICAHN School of Medicine at Mount Sinai Hospital, New York, NY, United States;1. Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;2. Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA;3. Division of Gastroenterology, Mount Sinai School of Medicine, New York, NY, USA;4. The Broad Institute of MIT and Harvard, Cambridge, MA, USA |
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| Abstract: | IntroductionNowadays, there is an increasing interest for alternative options in the treatment of inflammatory bowel diseases (IBDs) that combine efficacy and an adequate safety profile.MethodsThe intestinal anti-inflammatory effects of Serpylli herba, the officinal drug in the European Pharmacopeia composed by the aerial parts of wild thyme (Thymus serpyllum), were evaluated in the trinitrobenzenesulfonic acid (TNBS)-induced rat colitis and dextran sodium sulfate (DSS)-induced mouse colitis, which are well characterized experimental models with some resemblance to human IBD.ResultsS. herba extract exerted an intestinal anti-inflammatory effect in both experimental models of colitis, as evidenced both histologically, since it facilitated the tissue recovery of the damaged colon, and biochemically as showed by the improvement of the different inflammatory markers evaluated, including myeloperoxidase activity, glutathione content, and leukotriene B4 levels as well as the expression of the inducible proteins iNOS and COX-2. This beneficial effect was associated with the reduction in the expression of different cytokines, like TNFα, IL-1β, IFNγ, IL-6 and IL-17, the chemokine MCP-1, and the adhesion molecule ICAM-1, thus ameliorating the altered immune response associated with the colonic inflammation.ConclusionS. herba extract displays an anti-inflammatory effect on different models of rodent colitis that could be attributed to its immunomodulatory properties. |
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