Primary Cutaneous B-Cell Lymphomas |
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| Affiliation: | 1. Department of Pathology, Stanford Hospital and Clinics, 300 Pasteur Drive Room H2117, Stanford, CA 94305, USA;2. Department of Dermatology, Stanford Hospital and Clinics, 450 Broadway, Pavilion B 4th Floor, Redwood City, CA 94063, USA;1. Pathology Service, Massachusetts General Hospital, Boston, MA, USA;2. Department of Pathology, Harvard Medical School, Boston, MA, USA;1. Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida;2. Department of Pathology, University of Florida College of Medicine, Gainesville, Florida;3. Inform Diagnostics Research Institute, Irving, Texas;1. Department of Dermatology, Tri-Service General Hospital, Taipei, Taiwan;2. Department of Dermatology, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan;3. Department of Medicine, National Defense Medical Center, Taipei, Taiwan;4. Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan;5. Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan |
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| Abstract: | B-cell lymphomas occurring in the skin often tend to be of systemic origin with secondary cutaneous involvement. Primary cutaneous B-cell lymphomas tend to be indolent disorders, with the exception of primary cutaneous diffuse large B-cell lymphoma–leg type (PCDLBCL-LT). In indolent conditions, the distinction between cutaneous lymphoma and cutaneous lymphoid hyperplasia can be difficult. Integration of all available information, including the clinical setting, is crucial to arriving at the appropriate diagnosis. In this review, we cover the diagnostic approaches to primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and PCDLBCL-LT, and discuss their differential diagnosis. |
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| Keywords: | Lymphoma B cell Marginal zone lymphoma Follicle center lymphoma Diffuse large B-cell lymphoma Leg type |
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