Influence of metabolic syndrome and its components on subclinical organ damage in hypertensive perimenopausal women |
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| Institution: | 1. I Department of Cardiology, Invasive Electrocardiology and Hypertension, Jagiellonian University Medical College, University, Krakow, Poland;2. Department of Invasive Cardiology, Electrotherapy and Angiology, Nowy Sacz Hospital, Nowy Sacz, Poland;1. Department of Invasive Cardiology, Medical University in Bialystok, Bialystok, Poland;2. Department of Clinical Medicine, Medical University in Bialystok, Bialystok, Poland;3. Department of Nephrology, Transplantation with Dialysis Center, Medical University in Bialystok, Bialystok, Poland;4. Department of Cardiology, Medical University in Bialystok, Bialystok, Poland;5. Department of Cardiac Surgery, Medical University in Bialystok, Bialystok, Poland;1. 2nd Department of Internal Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania;2. Medical Informatics and Biostatistics Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania;3. Biochemistry Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania;1. Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan, China;2. Department of Preventive Medicine, Medical School, Hubei University for Nationalities, Enshi 445000, Hubei, China;3. Center for Disease Control and Prevention of Gan luo County, Ganluo 616850, Sichuan, China;4. Center for Disease Control and Prevention of Liangshan Prefecture, Xichang 615000, Sichuan, China;1. Department of Cardiology, Medical University of Bialystok, Bialystok, Poland;2. Department of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland |
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| Abstract: | PurposeWe investigated the association between metabolic syndrome (MS), its components and the presence of subclinical organ damage in hypertensive perimenopausal women.Patients/methods152 women with newly diagnosed, untreated arterial hypertension (mean age 51.0 ± 3.5 years) were included in the study. In all subjects anthropometrical measurements, 24-hr blood pressure monitoring, echocardiographic examination, and carotid ultrasound were performed. Carotid-femoral pulse wave velocity (PWV) was measured to obtain data on vascular compliance. As the index of early kidney damage both glomerular filtration rate was calculated and albumin/creatinine ratio in the urine sample was measured. A fasting blood sample was taken to measure glucose and lipid concentration.ResultsMS was found in 41% of patients. Patients with MS exhibited elevated left ventricular mass index (LVMI 84.7 vs. 78.8 g/m2.7, p = 0.03), higher intima-media thickness (IMT 0.67 vs. 0.62 mm, p = 0.003), greater prevalence of LV hypertrophy (30% vs. 13%, p = 0.01), and carotid plaques (24% vs. 15%, p = 0.01). The multivariate regression analysis revealed that components of MS (systolic blood pressure and waist circumference) are stronger predictors of LVM than MS itself. The relationship between MS and LVMI lost its significance when BMI was included in the model, and remained significant for IMT.ConclusionIn hypertensive perimenopausal women components of MS are stronger predictors of subclinical organ damage than MS itself. Left ventricular mass and hypertrophy are more strongly correlated with increasing body weight than with the presence of MS. MS, independently of BMI, influences the level of subclinical atherosclerosis in the study group. |
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| Keywords: | Metabolic syndrome Organ damage Hypertension Menopause |
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