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Progress in Novel Cellular Therapy Options for Chronic Lymphocytic Leukemia: The MD Anderson Perspective |
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| Institution: | 1. Department of stem cell transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas;2. Department of Pediatric, University of Texas Medical Branch, Galveston, Texas;3. Department of Hematology Oncology, Baylor College of Medicine, Houston, Texas;4. Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| Abstract: | Over the past several years there has been considerable progress in the number and breadth of therapeutic options for patients with chronic lymphocytic leukemia. In particular, cumulative experience with stem cell transplant and immunotherapy has made these modalities more available to a broader range of patients. Advances in genetic engineering and ex vivo expansion techniques have sculpted cellular therapy products to optimize the combination of specificity and toxicity. This brief review discusses recent cutting-edge experience with chimeric antigen receptor T cells as well as developing cellular therapy products at the authors' institution. |
| Keywords: | Chimeric antigen receptors Immunotherapy NK cells Stem cell transplant T cells |
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