| 骨碎补中的化学成分 |
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| 引用本文： | 高颖,WANG Xin-luan,王乃利,YAO Xin-sheng.骨碎补中的化学成分[J].中国药物化学杂志,2008,18(4):284-287. |
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| 作者姓名： | 高颖 WANG Xin-luan 王乃利 YAO Xin-sheng |
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| 作者单位： | 1. 沈阳药科大学,中药学院,辽宁,沈阳,110016
2. 沈阳药科大学,中药学院,辽宁,沈阳,110016;深圳清华大学研究院,深圳市创新中药及天然药物重点实验室,广东,深圳,518057 |
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| 基金项目： | 国家自然科学基金
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中-港合作项目 |
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| 摘 要： | 目的研究骨碎补（Drynaria fortunei）大孔吸附树脂柱色谱以体积分数50％乙醇洗脱部分的化学成分。方法利用硅胶、Sephadex LH-20、ODS柱色谱及制备型HPLC等方法进行分离纯化，根据化合物的理化性质及波谱数据鉴定结构。结果与结论从骨碎补大孔吸附树脂柱色谱50％乙醇洗脱部分分离鉴定了7个已知化学成分。分别为：山柰酚7-O-α-呋喃阿拉伯糖（1）、紫云英苷（2）、阿福豆苷（3）、北美圣草索（4）、3-乙酰胺基-4-羟基苯甲酸（5）、5-乙氧基-2-羟基苯甲酸乙酯（6）、β-谷甾醇（7）。化合物1～6为首次从该属植物中分离得到。
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| 关 键 词： | 骨碎补 化学成分 结构鉴定 柱色谱法 |
| 收稿时间： | 2008-3-11 |
| 修稿时间： | 2008-5-20 |
Chemical constituents from Drynaria Fortunei |
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| GAO Ying,WANG Xin-luan,WANG Nai-li,YAO Xin-sheng.Chemical constituents from Drynaria Fortunei[J].Chinese Journal of Medicinal Chemistry,2008,18(4):284-287. |
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| Authors: | GAO Ying WANG Xin-luan WANG Nai-li YAO Xin-sheng |
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| Institution: | (1.School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; 2.Key lab. for New Drugs Research of TCM., Shenzhen Research Institute of Tsinghua University, Shenzhen 518057, China; 3. Shenzhen Research Center of Traditional Chinese Medicine and Natural Products, shenzhen 518057, China) |
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| Abstract: | Abstract : Aim To further study the chemical constituents from the marcroporous adsorption resin 50% EtOH eluent of Drynaria fortunei. Methods The constituents in the marcroporous adsorption resin 50% EtOH eluent of Drynaria fortunei were isolated by a combination of silica gel, Sephadex LH-20 and ODS chromatographies and their structures were identified by spectral methods. Results Seven compounds were isolated. Their structures were identified by means of spectroscopic analysis as kaempferol-7-O-α-L-arabinofuranoside (1), astragalin (2), kaempferol-3-O-α-L-rhamnopyranoside (3), eriotictyol (4), 3-acetamino-4-hydroxy-benzoic acid (5), ethyl-5-ethoxy-2-hydroxy-benzoate (6) and β-sitosterol (7). Conclusion Compounds 1～6 were obtained for the first time from Drynaria fortunei. |
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| Keywords: | Drynaria Fortunei chemical constituents structural identification column chromatography |
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