细胞粘附因子CD44v6表达与肺癌转移和预后的关系

目的　探讨细胞粘附因子CD4 4v6在肺癌组织中的表达及其与肺癌的转移和预后的关系。方法　应用免疫组化SP法检测CD4 4v6在 79例肺癌组织中的表达情况。结果　伴淋巴结转移者CD4 4v6表达阳性率为4 5 .4 5 % ( 2 0 / 4 4 ) ,无淋巴结转移者CD4 4v6表达阳性率为 5 3.33% ( 2 1/ 35 ) ,其差异有显著性 (P <0 .0 5 )。CD4 4v6阳性者生存率与阴性者之间有一定差别 ,但无统计学意义 (P >0 .0 5 )。结论　CD4 4v6表达与肺癌淋巴结转移有一定的关系 ,但其作用有待于进一步探讨 ;CD4 4v6表达与肺癌短期预后无关

Expression of CD44v6 in patients with lung carcinoma and its relationship with lymph node metastasis and prognosis

Objective To study the expression of CD44v6 and its relationship with lymph node metastasis and prognosis in lung carcinoma. Methods Immunohistochemical method (SP method) was used to detect the expression of CD44v6 in 79 lung carcinoma specimens. Results The expression of CD44v6 was much lower in patients with lymph node metastasis than in those without (P<0.05). No significant difference in short-term survival rate was found between the patients with cancer tissue CD44v6 positive and negative separately. Conclusion The expression of CD44v6 is not an independent prognostic factor of lung carcinoma. It is closely related to lymph node metastasis, but its actual role needs further study.