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| 愈溃宁颗粒抗胃溃疡的药效学及急性毒性试验研究 | |
| 引用本文： | 索菲娅,崔俊杰,陈世忠. 愈溃宁颗粒抗胃溃疡的药效学及急性毒性试验研究[J]. 中成药, 2007, 29(2): 186-189 |
| 作者姓名： | 索菲娅 崔俊杰 陈世忠 |
| 作者单位： | 1. 北京大学药学院中药研究室,北京,100083;新疆大学生命科学与技术学院,新疆,乌鲁木齐,830046 2. 北京大学药学院中药研究室,北京,100083 3. 新疆大学生命科学与技术学院,新疆,乌鲁木齐,830046 |
| 摘 要： | 目的:探讨愈溃宁颗粒(海螵蛸、延胡索、炙黄芪、白芍、炙甘草等)(YKN)的抗胃溃疡的作用机制。方法:采用应激性刺激、幽门结扎性胃溃疡、醋酸致胃溃疡、乙醇致胃黏膜损伤大鼠模型观察YKN抗胃溃疡作用;对正常大鼠胃液分泌、胃液酸度、胃蛋白酶活性的影响及扭体法镇痛试验;小鼠一日最大耐受量。结果:与空白组相比,YKN可抵制溃疡的形成,降低大鼠胃溃疡指数,促进溃疡的愈合,抑制胃液分泌,降低胃液酸度,有降低胃蛋白酶活性,减少醋酸致痛小鼠的扭体次数的综合作用。一日最大耐受量相当于临床用量的288倍。结论:YKN具有明显抗溃疡的作用且无明显的毒副作用。 |
| 关 键 词： | 愈溃宁颗粒 药效学 急性毒性试验 小鼠 |
| 文章编号： | 1001-1528（2007）02-0186-03 |
| 修稿时间： | 2006-01-10 |
Experimental study on pharmacodynamic action of resisting gastric ulcer of Yukuining Granules and its acute toxicity |
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| SUO Fei-ya,CUI Jun-jie,CHEN Shi-zhong. Experimental study on pharmacodynamic action of resisting gastric ulcer of Yukuining Granules and its acute toxicity[J]. Chinese Traditional Patent Medicine, 2007, 29(2): 186-189 | |
| Authors: | SUO Fei-ya CUI Jun-jie CHEN Shi-zhong |
| Affiliation: | 1. Institute of Traditortal Chinese Medicine, School of Pharmacy, Beijing University, Beijing 100083, China; 2. The School of Biological Science and Technology, XinJiang University, Wulumuqi 830046, China |
| Abstract: | AIM: To explore Yukuining Granules(Endoconcha Sepiae,Rhizoma Corydalis,Radix Astragali praeparata cum melle,Radix Paeoniae Alba,Radix et Rhizoma Glycyrrhizae praeparata cum melle,etc) pharmacodynamic action of resisting gastric ulcer. METHODS: The rat's gastric ulcer models were induced by irritabal stimulus,pyloric ligation,acetic acid and ethanol-induced gastric mucosa injure,respectively.The ulcer was observed and the content of gastric juice,gastric acidity and pepsin were measured.Yukuining Granules pharmacodynamic action was also measured by observing its effect of alleviating pain on torsivesion malposition mice.The max dosage that mice could tolerate was recorded everyday. RESULTS: YKN Granules could significantly reduce the areas of ulcers,restrain gastric ulcer,promote gastric ulcer heal,reduce gastric juice volume,restrain gastric secretion and alleviate the pain induced by acetic acid in mice,The daily max tolerant dosage was equal to 288 times of clinical routine. CONCLUSION: YKN Granules have a marked anti-ulcerative effect and show the less side effect. |
| Keywords: | Yukuining Granules(YKN) phaemacodynamics actue toxicity experiment rat |
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