高敏C反应蛋白与急性脑梗死患者病情严重程度相关性研究

摘要目的探讨急性脑梗死患者入院早期高敏c反应蛋白（hs—CRP）与临床病情严重程度的关系。方法连续收集发病时间〈24h急性脑梗死患者272例，应用自制调查表收集研究对象的基本信息和疾病史，检测入院后24h内hs—CRP水平，同时收集患者入院后1，7，14d的NIHSS评分、mRS评分作为患者临床病情严重程度的综合判定指标。应用相关分析进行hs～CRP与NIHSS评分、mRS评分的相关性分析，多因素Logistic逐步回归分析找出影响患者7dNIHSS评分、mRS评分的独立危险因素。结果hs—CRP与入院后1，7，14dNIHSS评分，入院后1，7，14dinRS评分高度相关（P〈0．001）。hs—CRP是影响7dNIHSS评分及1TIRS评分的共同危险因子。结论hs—CRP是急性脑梗死病情危重的独立危险因子。

THE RELATIONSHIP BETWEEN HS - CRP AND THE SEVERITY OF ACUTE CEREBRAL INFARCTION

Objective To explore the relationship between the high- sensitivity C - reactive protein （hs - CRP） and the acute cerebral infarction. Methods A sample of 272 patients with acute cerebral infarction patients （onset 〈 24 hoursl were enrolled as our subjects. A selfmade questionnaire was used to collect the basic information and disease history of the patients, the hs - CRP level was detected in 24 hours after admission. At the same time, the NIHSS score and the mRS score of patients who were admitted to hospital after 1 day, 7 days, 14 clays were performed, which were served as the severity of clinical disease comprehensive index. Regression analysis was applied to analyze the relationship between the hs - CRP and the NIHSS score and the mRS score. Multiple factors Logistic stepwise regression analysis was used to look for the independent risk factors which influenced the NIHSS score and the mRS score of seventh day. Re- suits The hs - CRP and the NIHSS score of 1 day, 7 days, 14 days after admission, and the mRS score of 1 day, 7 days, 14 days after admission were highly correlated （ P〈0. 001 ）. Hs - CRP was the common risk factors which influenced the NIHSS score and the mRS score of 7 days. Conclusion The hs - CRP is an independent risk factor of acute cerebral infarction in a critical condition.