正畸牙移动对甲亢大鼠甲状腺素水平的影响

目的建立甲亢大鼠模型，探讨在高骨状态下正畸牙移动对甲状腺激素的影响。方法选取健康雄性Wistar大鼠50只，随机抽取10只按1ml／100g体重每天蒸馏水灌胃为正常对照组，余40只用等量优甲乐灌注胃建甲亢大鼠模型，28d建模成功，随后分为甲亢0、7、14、21、28d组，每组10只检测T3、T4、TSH。结果所有甲亢大鼠的T3、T4、TsH在正畸牙齿移动以后均稍有升高，其中以7d组升高最为明显，但差异均无统计学意义（P〉0．05）。结论①甲亢大鼠在正畸牙移动过程中有骨质疏松倾向，正畸牙移动治疗应使用轻力。②在正畸牙移动过程中，甲亢大鼠的甲状腺激素水平变化幅度小，提示短期正畸牙移动治疗对甲状腺激素水平无明显影响。

THE INFLUENCE OF THYROID HORMONE LEVELS BY ORTHODONTIC TOOTH MOVEMENT IN HYPER- THYROID RATS

Objective To evaluate the effect of orthodontic tooth movement on thyroid hormones in the con- dition of high bone. Methods Fifty adult Wistar male rats were randomly assigned to two groups, ran- domly selected 10 rats as normal control group, hyperthyroid rats model was established by given a garage of distilled water with lml/100g once a day for 4w, 40 rats as hyperthyroid group was given by gavage of euthyrox of the same volume and the same time with the distilled water. After model completed, hyperthy- roid group were subdivided in accordance with the tooth movemen time into 0 day group, 7 days group, 14 days group, 21 days group and 28 days group, the T3, T4 and TSH were detected in same period. Results After orthodontic tooth movement , thyroid hormone T3, T4 and TSH became higher than that before in hyperthyroid group, of which 7 days group increased obviously, but there was no statistical significance（P ~0.05）. Conclusions Due to a tendency of osteoporosis,orthodontic tooth movement therapy of hyper- thyroid rats should use light force. In the process of orthodontic tooth movement, thyroid hormone levels in hyperthyroid rats variedwithin a small range. Therefore remind that short - term orthodontic tooth movement therapy have no obvious effect on thyroid hormone levels.