| β—杂环酰胺基丙基锗倍半硫化物的合成和抗癌活性 |
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| 引用本文： | 上官国强 郭承芳. β—杂环酰胺基丙基锗倍半硫化物的合成和抗癌活性[J]. 济宁医学院学报, 1997, 20(2): 1-3 |
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| 作者姓名： | 上官国强 郭承芳 |
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| 作者单位： | [1]济宁医学院化学教研室 [2]曲阜市卫生防疫站 |
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| 摘 要： | 用α－丙基丙烯酸、二氧化锗，杂环胺、硫化氢等原料合成了６种新型有机锗化合物－β－杂环酰胺基丙左锗倍半硫化物，用多种现代测试方法研究了它们的组成、结构特征和理化性质，Ｇｅ－Ｓ特征吸收峰为４００￣４３０ｃｍ＾－１，Ｇｅ３ｄ和Ｇｅ３ｐ的电子结合能分别为３１．６￣３１．８ｅｖ和１２３。７￣１２４．０ｅｖ，系列化合物结构相似、Ｇｅ原子周围化学环境基本相同。对其中４种化合物进行了体外Ｈｅｌａ细胞培养实验，结果
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| 关 键 词： | 有机锗化合物 合成 抗癌活性 |
THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF ORGANOGERMANIUM SESQUISULFIDES WITH HETEROCYCLOAMINES |
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| Shangguan Guoqiang,Guo Chengfang,Wang Hongen,et al.. THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF ORGANOGERMANIUM SESQUISULFIDES WITH HETEROCYCLOAMINES[J]. Jounal of Jinning Medical College, 1997, 20(2): 1-3 |
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| Authors: | Shangguan Guoqiang Guo Chengfang Wang Hongen et al. |
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| Abstract: | Six organogermanium sesquisulfides with heterocycloamines were synthesized,their compositions and structures were determined by elemental analysis and IR spectra. In the IR spectra,there were the characteristic absorpation bands of Ge-S bonds at 400-430cm -1 ,indicating the formation of organogermanium sesquisulfides. Four of the compounds were tested for the antitumor activities against Hela cells in vitro.The results showed that the compounds had considerable tumor inhibitory activities. |
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| Keywords: | Organogermanirm compound Synthesis Antitumor activity |
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