壳聚糖宫颈抗菌膜在宫颈环形电切术后的应用研究

目的：观察壳聚糖宫颈抗菌膜在宫颈环形电切术（LEEP）治疗后，减少创面感染、促使创面愈合及预防术后出血的临床效果，寻求预防宫颈环切术后并发症的有效方法。方法选择进行LEEP术治疗的宫颈疾病患者200例，随机分成两组，LEEP术后采用壳聚糖宫颈抗菌膜创面上药者100例作为治疗组，LEEP术后自然修复100例作为对照组。对照组发生出血量多时用云南白药和甲硝唑药粉混合局部上药止血。结果观察组阴道出血量、流液量及流血持续时间少于对照组（P＜0.05）；观察组白带异常情况明显少于对照组（P＜0.05）；创面愈合总有效率两组差异无统计学意义，术后2个月和3个月观察痊愈率，观察组与对照组比较差异有统计学意义（P＜0.05）。结论壳聚糖宫颈抗菌膜具有局部抗菌、止血及促进术后创面愈合作用，使宫颈愈合时间缩短，减少创面感染、渗出、出血，以及LEEP术后并发症。

Clinical observation of Cervical Chitosan Antimicrobial Film on patients who after loop electrosurgical excision procedure

Objective With the application of cervical chitosan antibacterial film, this study was aimed to explore an effective method to prevent the postoperative complications after loop electrosurgical excision procedure（LEEP）by observing the clinical effect to reduce wound infection, promote wound healing and prevent postoperative bleeding. Methods 200 cases of patients with chronic cervicitis needing LEEP were divied into two groups randomly. After LEEP, cervical chitosan antimicrobial film was applied in 100 cases in the treatment group, LEEP after the natural repair in 100 cases as control group. The control group bleeding time with Yunnan Baiyao and metronidazole powder mixed medicinehemostatic. Results The treatment group of vaginal bleeding, vaginal fluid, and the duration of vaginal bleeding was less than that of the control group（P〈0.05 ）.The treated group leucorrhea abnormal conditions had obvious difference（P〈0.05）. Wound healing, the total efficiency of two groups had no statistical significance, but the cure rate after 2months compared with 3 months to observe the treatment group and the control group had statistical significance（P〈0.05 ）. Conclusion Chitosan cervical antibacterial film with topical anti bacterial, hemostatic and wound healing promoting effects of postoper ativecervical, the healing time was shortened, reducing wound infection, oozing, bleeding, and postoperative complications.