| A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum简 |
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| 引用本文： | LIU Dan,QU Wei,ZHAO Ling,GUAN Fu-Qin,LIANG Jing-Yu. A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum简[J]. 中国天然药物, 2014, 0(2): 139-141 |
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| 作者姓名： | LIU Dan QU Wei ZHAO Ling GUAN Fu-Qin LIANG Jing-Yu |
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| 基金项目： | This project was supported by the Fundamental Research Funds for the Central Universities, China （No, JKY2011015）. |
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| 摘 要： | AIM： To study the chemical constituents of the rhizomes ofAlpinia officinarum Hance. METHOD： Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B 16F10 cell lines by the MTT assay. RESULTS： A dimeric diarylheptanoid, named alpinin B （1）, along with three known diarylheptanoids were obtained, and their structures were identified as alpinin B （1）, 1, 7-diphenyl-3,5-heptanedione （2）, （4E）-1, 7-diphenylhept-4-en-3-one （3） and （4E）-7- （4-hydroxyphenyl）- 1-phenylhept-4-en-3-one （4）. CONCLUSION： Compound 1 is a new dimeric diarylheptanoid. The biosynthetic pathway of 1 was speculated to originate from a Michael reaction between compounds 2 and 3. Compound 3 showed cytotoxicity against the human glioblastoma T98G cell line with IC50 of 27 μmol·L-1.
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| 关 键 词： | Alpinia officinarum Hance diarylheptanoid alpinin B 1,7-diphenyl-3,5-heptanedione （4E）-l,7-diphenylhept-4-en -3-one |
A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum |
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| LIU Dan,QU Wei,ZHAO Ling,GUAN Fu-Qin,LIANG Jing-Yu. A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum[J]. Chinese JOurnal of Natural Medicines, 2014, 0(2): 139-141 |
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| Authors: | LIU Dan QU Wei ZHAO Ling GUAN Fu-Qin LIANG Jing-Yu |
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| Affiliation: | [1]Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China,＂ [2]College of Biotechnology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China; [3]institute of Botany, diangsu Province and Chinese Academy of Science, Nanjing 210014, China |
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