非透析慢性肾脏病患者肌酐与血色素的定量关系

目的:探讨非透析慢性肾脏病患者肌酐(Cr)与血色素(Hb)关系及临床意义。方法:分别入选慢性肾脏病组病例46例,慢性肾功能不全急性加重组7例,慢性肾脏病伴多因素贫血组6例,同时检测血肌酐及血色素水平,对肌酐增加值及血色素进行相关分析及线性回归分析,对三组的数据进行肌酐增加值/10+血色素的计算并进行比较。结果:①慢性肾脏病组肌酐水平低于慢性肾功能不全急性加重组高于慢性肾脏病多因素贫血组(P<0.05)。②慢性肾脏病组肌酐增加值及血色素呈明显负相关(r=-0.841,P<0.001)。以血色素为自变量,肌酐增加值为应变量进行线性回归分析,常数项α=1 308.23±103.52,斜率β=-9.87±0.95,取整数-10为斜率β的取值进行肌酐增加值/10+血色素计算。③三组数据分别进行肌酐增加值/10+血色素的计算,慢性肾脏病组计算值水平低于慢性肾功能不全急性加重组高于慢性肾脏病多因素贫血组(P<0.001)。结论:非透析慢性肾脏病患者随肌酐水平的增加,血色素进行性下降,且有血肌酐升高约10μmol/L血色素下降1 g/L的趋势。

Relationship between creatinine and hemoglobin of pre-dialysis chronic kidney disease

Objective To study the relationship between creatinine(Cr) and hemoglobin(Hb) of pre-dialysis chronic kidney disease and its clinical significance.Method A total of 59 pre-dialysis chronic kidney patients were selected and divided into chronic kidney disease group(n=46),chronic renal insufficiency group with acute attack group(n=7),chronic kidney disease with multifactor anemia group(n=6),serum creatinine and hemoglobin were simultaneously detected,correlation and linear regression analysis between increased creatinine and hemoglobin were conducted.Increasing of creatinine/10+hemoglobin was calculated among three groups.Results ①Creatinine level of chronic kidney disease group was lower than chronic renal insufficiency with acute exacerbation group and higher than that of chronic kidney disease with multifactor anemia group(P<0.05).② There was a significant negative correlation(r=-0.841,P<0.001) between increased creatinine and hemoglobin.In chronic kidney disease group,hemoglobin as independent variables,increased creatinine as dependent variable,linear regression analysis was conducted,the constant α=1308.23 ±103.52,the slope β=-9.87±0.95,-10 was selected in slope β,increased creatinine/10+hemoglobin was calculated.③ Calculated results of chronic kidney disease group was lower than those of chronic renal insufficiency with acute exacerbation group and higher than those of chronic kidney disease with multifactor anemia group(P<0.001).Conclusion Decreasing of hemoglobin gradually is accompanied with increasing of creatinine in pre-dialysis chronic kidney disease patients,and there is a trend that serum creatinine increases by about 10 μmol/L with hemoglobin decreasing 1 g/L