Phenobarbital induction of CYP6D1 is due to a trans acting factor on autosome 2 in house flies, Musca domestica |
| |
| Authors: | N. Liu,& J. G. Scott |
| |
| Affiliation: | Department of Entomology, Comstock Hall,Cornell University, Ithaca, New York, USA |
| |
| Abstract: | To improve our understanding of phenobarbital (PB) mediated induction of CYP6D1 we examined the genetic linkage of PB induction using PB responsive (aabys) and non-responsive (LPR) strains of house flies. PB induction was linked to autosome 2, indicating that CYP6D1 is trans regulated by this PB inducible element. Our results are discussed relative to a previous hypothesis that the same regulatory genes are responsible for both induction and monooxygenase-mediated insecticide resistance. |
| |
| Keywords: | |
|
|
