Pilocarpine-induced purposeless chewing behaviour in rats is dependent on intact central stores of 5-HT |
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| Authors: | B Stewart S Rose P Jenner C D Marsden |
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| Affiliation: | MRC Movement Disorders Research Group, University Department of Neurology, London, U.K. |
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| Abstract: | Pilocarpine-induced purposeless chewing behaviour in rats was partially antagonised by pretreatment with reserpine, tetrabenazine or p-chlorophenylalanine (PCPA). In contrast, pretreatment with alpha-methyl-p-tyrosine (AMPT) had no effect on pilocarpine-induced chewing. These data suggest that enhancement of purposeless chewing by pilocarpine is dependent, in part, on intact central stores of 5-HT. |
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