CEUS定量分析鉴别诊断乳腺肿瘤的价值及其与微血管密度的相关性分析

目的 采用CEUS时间-强度曲线(TICs)各参数鉴别良恶性肿瘤的价值及其与微血管密度(MVD)间的关系。方法 纳入获得病理诊断的患者79例,其中良性病变56例,恶性病变23 例。手术病理标本切片行免疫组织化学染色检测MVD。采用SonoLiver软件定量分析各参数与MVD关系。结果 乳腺病灶TICs的各参数在良恶性肿瘤之间比较差异无统计学意义(P>0.05);乳腺病灶的IMAX 及QOF明显高于乳腺实质,而且RT、TTP、mTT均较乳腺实质短(P <0.05)。恶性病灶MVD数目为(173.16±64.67)个/mm²,良性病灶MVD数目为(149.01±35.16)个/mm²,差异有统计学意义(P =0.04)。TICs各参数只有IMAX与MVD相关(r=0.229,P=0.048)。结论 乳腺病变CEUS定量参数的IMAX与MVD存在正相关,通过定量分析的峰值强度参数可以初步评估乳腺肿瘤内微血管密度。

Quantitative assessment of CEUS in differentiating breast tumors and correlation with microvessel density

Objective To explore the value of the parameters of CEUS time-intensity curves (TICs) in differentiating breast tumors and its correlation with microvessel density (MVD). Methods Totally 79 patients confirmed by pathology were enrolled, including 56 benign and 23 malignant lesions. MVD was examined after immunohistochemistry. Relationship of the parameters of TICs with MVD were analyzed by SonoLiver software. Results There were no significant difference of tumor's maximum intensity (IMAX), rise time (RT), time to peak (TTP), mean transit time (mTT) and quality of fit (QOF) between malignant and benign breast lesions (P>0.05). IMAX and QOF of tumors were higher than that of the parenchyma, whereas RT, TTP, and mTT of tumors were shorter than those of the parenchyma (all P<0.05). MVD in malignant breast lesions was more than that in benign lesions (173.16±64.67]/mm² vs 149.01±35.16]/mm², P=0.040). Among all these parameters in TICs, only IMAX had positive correlation with MVD (r=0.229, P=0.048). Conclusion IMAX of breast lesions has positive correlation with MVD, and it can initially assess tumor's MVD.