130例肺炎支原体感染所致儿童慢性咳嗽的治疗研究

目的分析肺炎支原体（MP）感染与儿童慢性咳嗽的关系，综合血清学试验结果，探讨以大环内酯序贯疗法为主的治疗效果。方法对2011年5月至2012年5月在我院就诊的270例慢性咳嗽儿童采用被动凝集法检测血清MP—IgM抗体进行比较，将130例MP—IgM阳性者分为观察组及对照组。观察组给予大环内酯序贯疗法，对照组给予阿奇霉素治疗，并观察疗效。结果观察组与对照组治疗有效率分别为97．0％、85．9％，差异有统计学意义（P〈0．05）；观察组与对照组血清MP—IgM总转阴率分别为95．5％、82．8％，差异有统计学意义（P〈0．05）。结论MP感染是引起儿童慢性咳嗽的重要致病因素之一，大环内酯类抗生素序贯治疗为主的疗法具有较好的疗效。

Study on the treatment of 130 cases of chronic cough in children caused by mycoplasma pneumoniae infection

Abstract ] Objective To analyze the correlation between mycoplasma pneumoniae （MP） infection and chronic cough in children, according to the test results of serological, discuss the macrolides sequential therapy effect. Methods From May 2011 to May 2012 in our hospital 270 cases of chronic cough in children were detected serum MP-IgM antibody by passive agglutination method, 130 cases were MP-IgM positive, divided into observation group and control group. The observation group was given macrolide sequential therapy, control group received azithromycin treatment, and we observed the effects of two groups. Results The treatment efficiency： the observation group andthe control group were 97.0% and 85.9% respectively （P〈0.05） , with statistical significance; total serum MP- IGM negative rate： the observation group and the control group were 95.5% and 82.$% respectively （P〈0.05） , with statistical significance. Conclusion MP infection is one of the important pathogenic factors of chronic cough in children, macrolide antibiotic sequential therapy treatment has a better curative effect.