Polymorphous ventricular tachycardia due to alpha-blockade |
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| Authors: | M A James W Culling J Vann Jones |
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| Affiliation: | 1. Department of Biology, Genetics Institute, Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL 32610, USA;2. Department of Biology, Penn State University, 208 Mueller Laboratory, University Park, PA 16802, USA;3. Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32610, USA |
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| Abstract: | We report a case of polymorphous ventricular tachycardia caused by treatment with the post-synaptic alpha-blocking agent indoramin. This has not been reported with indoramin previously, nor to our knowledge with any other alpha-blocker. This pro-arrhythmic effect appears to be related to its class 3 anti-arrhythmic properties (QT interval prolongation) which is dose dependent, occurring only at large doses. |
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