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The association of myeloperoxidase promoter polymorphism with carotid atherosclerosis is abolished in patients with type 2 diabetes |
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| Authors: | Mäkelä Riikka Loimaala Antti Nenonen Arja Mercuri Michele Vuori Ilkka Huhtala Heini Oja Pekka Bond Gene Koivula Timo Lehtimäki Terho |
| Institution: | aTampere University Hospital, Centre for Laboratory Medicine, Department of Clinical Chemistry, Tampere, Finland bUniversity of Tampere, Department of Public Health Tampere, Finland cUniversity of Tampere Medical School, Tampere, Finland dSeinäjoki Central Hospital, Department of Clinical Physiology and Nuclear Medicine, Seinäjoki, Finland eUKK Institute for Health Promotion Research, Tampere, Finland fRheumatism Foundation Hospital, Heinola, Finland gWake Forest University School of Medicine, Winston-Salem, North Carolina, USA |
| Abstract: | ObjectivesType 2 diabetes mellitus (DM) enhances the development of atherosclerosis and reduces the activity of the oxidative myeloperoxidase (MPO) enzyme. MPO gene has a functional promoter polymorphism ?463G/A which leads to high- (GG) and low-expression (AG, AA) genotypes.Design and methodsWe studied the association of MPO polymorphism with carotid artery intima-media thickness (IMT) in 198 randomly selected Finnish men of Caucasian origin, 161 non-diabetics and 37 with type 2 DM. Their carotid IMT was measured by high-resolution ultrasonography, and the overall mean IMT value was calculated. MPO genotypes were determined by the PCR-RFLP method.ResultsWe found significant MPO genotype-by-study-group (control/DM) interactions with the overall mean IMT and internal carotid IMT (p = 0.05 and p = 0.04, respectively). Among non-diabetic subjects, the overall carotid IMT was 7.3% higher in subjects with the low-activity genotype when compared to the high-activity (G/G) group. The results remained significant after adjustment for total cholesterol and smoking (p = 0.015). No similar genotypic association was found for the subjects with type 2 DM.ConclusionsThis data suggests that in subjects with normal glucose metabolism, MPO gene variation may modify the carotid artery IMT. |
| Keywords: | Myeloperoxidase Carotid atherosclerosis Polymorphism Type 2 diabetes |
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