| 甲状腺功能对磺胺嘧啶在大鼠体内药动学的影响 |
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| 引用本文： | 但汉雄,江南,刘翠霞. 甲状腺功能对磺胺嘧啶在大鼠体内药动学的影响[J]. 中国药师, 2004, 7(8): 577-579 |
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| 作者姓名： | 但汉雄 江南 刘翠霞 |
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| 作者单位： | 湖北中医学院,武汉,430064 |
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| 摘 要： | 目的: 测定不同甲状腺功能状态时大鼠血液中磺胺嘧啶钠(SD)的浓度,研究甲状腺功能状态对其药代动力学的影响.方法: 采用分光光度计比色法测定技术.结果: 甲亢组大鼠磺胺嘧啶在体内消除加速,峰浓度下降,AUC减少,消除t1/2缩短.甲减组大鼠则消除减慢,峰浓度增高,AUC增大,消除t1/2延长.结论: 甲状腺功能提高时,大鼠对磺胺嘧啶的代谢能力明显增加,消除加速;而甲状腺功能降低则相反.
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| 关 键 词： | 药动学 甲状腺 磺胺嘧啶 药物代谢 |
| 文章编号： | 1008-049X(2004)08-0577-03 |
| 修稿时间： | 2003-11-11 |
Influence of Thyroid Function on Pharmakinetics of Sulfadiazine in Rats |
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| Dan Hanxiong,Jiang Nan,Liu Cuixia. Influence of Thyroid Function on Pharmakinetics of Sulfadiazine in Rats[J]. China Pharmacist, 2004, 7(8): 577-579 |
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| Authors: | Dan Hanxiong Jiang Nan Liu Cuixia |
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| Abstract: | Objective: To observe the influence of thyroid function on metabolism of sulfadiazine in rats.Method: Spectrophotometry method was used to determine the blood concentrations of sulfadiazine from rats with different thyroid function.Result: Sulfadiazine metabolized rapidly in the rats with hyperthyroidism, the C max and AUC were decreased, and the t 1/2 was cut short,but it showed an opposite results in the rats with hypothyroidism.Conclusion: Metabolism of sulfadiazine increases in rats with hyperthyroidism. |
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| Keywords: | Pharmacokinetics Thyroid Sulfadiazine Drug metabolism |
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