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| 7.0T MRI及Micro-PET无创检测小鼠动脉粥样硬化 | |
| 引用本文： | 王中娟,邓钢,黄洪波,李爱梅,居胜红,赵瑞,金晖,魏晓莹. 7.0T MRI及Micro-PET无创检测小鼠动脉粥样硬化[J]. 中国医学影像技术, 2010, 26(2): 209-212 |
| 作者姓名： | 王中娟 邓钢 黄洪波 李爱梅 居胜红 赵瑞 金晖 魏晓莹 |
| 作者单位： | 1. 东南大学附属中大医院放射科,江苏,南京,210009 2. 江苏省原子能医学研究所,卫生部核医学重点实验室,江苏,无锡,214063 3. 南京大学医学院附属鼓楼医院PET/CT中心,江苏,南京,210009 |
| 摘 要： | 目的 探讨7.0T小动物MRI及Micro-PET检测动脉粥样硬化的可行性.方法 取10只46周龄ApoE-/-小鼠建立老年ApoE-/-小鼠动脉粥样硬化模型,取5只模型于鼠尾静脉注射超顺磁性氧化铁(SPIO)前、后12 h、24 h、36 h 行MR扫描(应用7.0TMR仪);另5只模型于鼠尾静脉注射18F-氟脱氧葡萄糖(~(18)F-FDG)1 h、2 h、3 h后行Micro-PET显像;取腹主动脉行病理检查.结果 老年ApoE-/-小鼠高脂喂养6个月后,7.0T MRI证实动脉粥样硬化斑块形成;鼠尾静脉注射SPIO后36 h发现鼠腹主动脉及两侧髂动脉血管壁T2W像上环形高信号较未注射SPIO前变薄,血管腔较前增宽.鼠尾静脉注射~(18)F-FDG行Micro-PET检测,发现在3 h左右腹主动脉及两侧髂动脉区域有放射性浓聚.病理示腹主动脉壁内有动脉粥样硬化斑块形成及巨噬细胞的聚集.结论 7.0T MRI及Micro-PET可成功检测巨噬细胞丰富的动脉粥样硬化斑块,有助于判断斑块的易损性,为早期发现、诊断及治疗动脉粥样硬化提供理论依据. |
| 关 键 词： | 动脉硬化 巨噬细胞 磁共振 ApoE-/-小鼠 |
| 收稿时间： | 2009-08-28 |
| 修稿时间： | 2009-11-17 |
Noninvasive observation of atherosclerosis in mice with 7.0T MR and Micro-PET |
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| WANG Zhong-juan,DENG Gang,HUANG Hong-bo,LI Ai-mei,JU Sheng-hong,ZHAO Rui,JIN Hui and WEI Xiao-ying. Noninvasive observation of atherosclerosis in mice with 7.0T MR and Micro-PET[J]. Chinese Journal of Medical Imaging Technology, 2010, 26(2): 209-212 | |
| Authors: | WANG Zhong-juan DENG Gang HUANG Hong-bo LI Ai-mei JU Sheng-hong ZHAO Rui JIN Hui WEI Xiao-ying |
| Affiliation: | Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China;Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China;Jiangsu Institute of Nuclear Medicine, Key Laboratory of Nuclear Medicine, Ministry of Health, Wuxi 214063, China;PET/CT Center, the Affiliated DrumTower Hospital of Nanjing University Medical School, Nanjing 210009, China;Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China;Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China;Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China;Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China |
| Abstract: | Objective To explore the feasibility of detecting atherosclerosis with 7.0T MR and Micro-PET.Methods Ten 46-week-old ApoE-/-mice with high lipid diet for 6 months were selected to establish atherosclerosis models.Among them,5 mice underwent MRI before and 12 h,24 h,36 h after injection of SPIO,respectively,and the other 5 mice were injected with 18F-fluorodeoxyglucose (18F-FDG) through tail vein and observed with Micro-PET after 1 h,2 h and 3 h.The specimens of abdominal aorta were taken for pathologic exam... |
| Keywords: | Micro-PET Atherosclerosis Macrophage Magnetic resonance imaging Micro-PET ApoE-/-mice |
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