Validation of a method to screen for pulmonary hypertension in advanced idiopathic pulmonary fibrosis |
| |
Authors: | Zisman David A Karlamangla Arun S Kawut Steven M Shlobin Oksana A Saggar Rajeev Ross David J Schwarz Marvin I Belperio John A Ardehali Abbas Lynch Joseph P Nathan Steven D |
| |
Affiliation: | Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. dzisman@mednet.ucla.edu |
| |
Abstract: | BACKGROUND: We have developed a method to screen for pulmonary hypertension (PH) in idiopathic pulmonary fibrosis (IPF) patients, based on a formula to predict mean pulmonary artery pressure (MPAP) from standard lung function measurements. The objective of this study was to validate this method in a separate group of IPF patients. METHODS: Cross-sectional study of 60 IPF patients from two institutions. The accuracy of the MPAP estimation was assessed by examining the correlation between the predicted and measured MPAPs and the magnitude of the estimation error. The discriminatory ability of the method for PH was assessed using the area under the receiver operating characteristic curve (AUC). RESULTS: There was strong correlation in the expected direction between the predicted and measured MPAPs (r = 0.72; p < 0.0001). The estimated MPAP was within 5 mm Hg of the measured MPAP 72% of the time. The AUC for predicting PH was 0.85, and did not differ by institution. A formula-predicted MPAP > 21 mm Hg was associated with a sensitivity, specificity, positive predictive value, and negative predictive value of 95%, 58%, 51%, and 96%, respectively, for PH defined as MPAP from right-heart catheterization > 25 mm Hg. CONCLUSIONS: A prediction formula for MPAP using standard lung function measurements can be used to screen for PH in IPF patients. |
| |
Keywords: | idiopathic pulmonary fibrosis prediction pulmonary fibrosis pulmonary hypertension AUC" },{" #name" :" keyword" ," $" :{" id" :" cekeyw40" }," $$" :[{" #name" :" text" ," _" :" area under the receiver operating characteristic curve CI" },{" #name" :" keyword" ," $" :{" id" :" cekeyw60" }," $$" :[{" #name" :" text" ," _" :" confidence interval diffusing capacity of the lung for carbon monoxide IPF" },{" #name" :" keyword" ," $" :{" id" :" cekeyw80" }," $$" :[{" #name" :" text" ," _" :" idiopathic pulmonary fibrosis MPAP" },{" #name" :" keyword" ," $" :{" id" :" cekeyw90" }," $$" :[{" #name" :" text" ," _" :" mean pulmonary artery pressure NPV" },{" #name" :" keyword" ," $" :{" id" :" cekeyw100" }," $$" :[{" #name" :" text" ," _" :" negative predictive value PFT" },{" #name" :" keyword" ," $" :{" id" :" cekeyw110" }," $$" :[{" #name" :" text" ," _" :" pulmonary function test PH" },{" #name" :" keyword" ," $" :{" id" :" cekeyw120" }," $$" :[{" #name" :" text" ," _" :" pulmonary hypertension PPV" },{" #name" :" keyword" ," $" :{" id" :" cekeyw130" }," $$" :[{" #name" :" text" ," _" :" positive predictive value RHC" },{" #name" :" keyword" ," $" :{" id" :" cekeyw140" }," $$" :[{" #name" :" text" ," _" :" right-heart catheterization resting room air pulse oximetry UCLA" },{" #name" :" keyword" ," $" :{" id" :" cekeyw160" }," $$" :[{" #name" :" text" ," _" :" University of California, Los Angeles |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|