| GLP-1在2型糖尿病诱发的阿尔茨海默病治疗中的作用 |
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| 引用本文： | 齐利琴,刘礼斌. GLP-1在2型糖尿病诱发的阿尔茨海默病治疗中的作用[J]. 国际内分泌代谢杂志, 2016, 0(1): 48-51. DOI: 10.3760/cma.j.issn.1673-4157.2016.01.012 |
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| 作者姓名： | 齐利琴 刘礼斌 |
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| 作者单位： | 350001福州,福建医科大学附属协和医院内分泌科,福建省内分泌研究所 |
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| 摘 要： | 2型糖尿病是诱发阿尔茨海默病的高危因素.胰高血糖素样肽-1(GLP-1)可诱导胰岛β细胞再生和增殖,可以呈葡萄糖依赖性地促进胰岛素分泌.另外,GLP-1在治疗神经退行性病变中也有重要的作用,能降低脑内β淀粉样蛋白斑块沉积,减少氧化应激引起的神经细胞损伤,还可以调节突触的传递,增加突触的可塑性,刺激轴突生长,影响长时程增强,从而改善记忆并提高认知水平.
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| 关 键 词： | 胰高血糖素样肽-1 2型糖尿病 阿尔茨海默病 |
Effects of GLP-1 in the treatment of Alzheimer's disease induced by type 2 diabetes mellitus |
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| Abstract: | Type 2 diabetes has been identified as a risk factor for Alzheimer's disease (AD).Glucagon-like peptide-1 (GLP-1) can stimulate β cell proliferation and insulin secretion in a glucose-dependent manner.It has been shown that GLP-1 also plays important roles in the treatment of neurodegenerative disease, such as reversing the detrimental effects that β-amyloid plaque load in brain, preventing neurons from oxidative damage, modulating synaptic transmission, rescuing synaptic plasticity, stimulating neurite growth, and affecting the process of long-term potentiation.Thus it can improve memory and cognitive dysfunction. |
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| Keywords: | Glucagon-like peptide-1 Type 2 diabetes mellitus Alzheimer's disease |
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