| PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展 |
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| 引用本文： | 许飞,刘建军,黄钢,宋少莉. PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J]. 国际放射医学核医学杂志, 2016, 40(1): 35-43. DOI: 10.3760/cma.j.issn.1673-4114.2016.01.008 |
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| 作者姓名： | 许飞 刘建军 黄钢 宋少莉 |
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| 作者单位： | 200127, 上海交通大学医学院附属仁济医院核医学科 |
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| 摘 要： | 放射性核素标记的乏氧显像是评估肿瘤乏氧程度的重要方法, 乏氧显像剂可以选择性地滞留于乏氧组织内, 直观反映乏氧的部位和乏氧的程度, 对肿瘤诊断、分期、疗效监测及预后评估等有指导意义, 同时也为临床选择及调整肿瘤治疗方案提供了客观依据。笔者主要对肿瘤乏氧PET显像近年来在临床研究中的进展及与肿瘤乏氧相关的治疗进展进行综述。
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| 关 键 词： | 肿瘤 正电子发射断层显像术 乏氧 |
| 收稿时间： | 2015-09-09 |
The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy |
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| Fei Xu,Jianjun Liu,Gang Huang,Shaoli Song. The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2016, 40(1): 35-43. DOI: 10.3760/cma.j.issn.1673-4114.2016.01.008 |
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| Authors: | Fei Xu Jianjun Liu Gang Huang Shaoli Song |
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| Affiliation: | Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China |
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| Abstract: | Assessing tumor hypoxia with metabolic imaging is an attractive alternative.Hypoxia tracers bind selectively to hypoxic cells, using PET with specific radiopharmaceuticals could visualize hypoxia noninvasively.Hypoxia PET imaging is a valuable tool in assessing oxygenation levels in tumors for the purpose of tumor diagnosis and also as a prognostic indicator.Meanwhile, hypoxia imaging can quantify hypoxic tumor subvolumes for dose painting and personalized treatment planning and delivery.This review summarizes the published literature on clinical studies and the experimental treatment of tumor hypoxia. |
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| Keywords: | Neoplasms Positron-emission tomography Hypoxia |
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