High expression of Lewis<Superscript>y/b</Superscript>antigens is associated with decreased survival in lymph node negative breast carcinomas期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

High expression of Lewisy/bantigens is associated with decreased survival in lymph node negative breast carcinomas

Authors:	Zahra?Madjd,Tina?Parsons,Nicholas?FS?Watson,Ian?Spendlove,Ian?Ellis,Lindy?G?Durrant author-information" > author-information__contact u-icon-before" > mailto:lindy.durrant@nottingham.ac.uk" title=" lindy.durrant@nottingham.ac.uk" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Academic Department of Clinical Oncology, Institute of Infections Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, UK;(2) Scancell Ltd, BioCity, Nottingham, UK;(3) Department of Histopathology, City Hospital, Nottingham, UK

Abstract:	Introduction There is sufficient evidence that blood group related Lewis antigens are tumour-associated molecules. The Lewis^y and Lewis^b antigens are complex carbohydrates that are over-expressed by breast, lung, colon and ovarian cancers. The SC101 mAb is a unique Lewis^y/b binding antibody that binds to native and extended Lewis^y and Lewis^b haptens, displaying no cross reactivity with H type 1, H type 2, Lewis^x or normal blood group antigens.

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