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MRI of optic nerve and postchiasmal visual pathways and visual evoked potentials in secondary progressive multiple sclerosis |
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| Authors: | M. B. Davies R. Williams N. Haq L. Pelosi C. P. Hawkins |
| Affiliation: | (1) School of Postgraduate Medicine, Keele University, Department of Neurology and Neurophysiology, Royal Infirmary, North Staffordshire Hospital, Stoke-on-Trent, England, ST4 7LN; Tel.: + 17 82-55 50 08, Fax: + 17 82-55 50 08, GB;(2) Department of Neurology and Neurophysiology, Royal Infirmary, North Staffordshire Hospital, Stoke-on-Trent, England, ST4 7LN, GB;(3) Department of Neurology, Royal Infirmary, North Staffordshire Hospital, Stoke-on-Trent, England ST4 7LN, GB;(4) MRI Unit Cornwall House, Stoke-on-Trent, England ST4 7LN, GB |
| Abstract: | We studied the relationship between abnormalities shown by MRI and functional disturbances in the visual pathway as assessed by the visual evoked potential (VEP) in 25 patients with established multiple sclerosis (MS); only 4 of whom had a history of acute optic neuritis. Optic nerve MRI was abnormal in 19 (76 %) and is thus useful in detecting subclinical disease. Optic nerve total lesion length and area on the STIR sequence was found to correlate significantly with prolongation of the VEP latency. This may reflect a predominantly demyelinating rather than inflammatory origin for the signal change in the optic nerve. Received: 21 July 1997 Accepted: 1 April 1998 |
| Keywords: | Multiple sclerosis Visual evoked potentials Magnetic resonance imaging |
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