Clusterin and Chemotherapy Sensitivity Under Normoxic and Graded Hypoxic Conditions in Colorectal Cancer |
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| Authors: | David Kevans Sheeona Gorman Miriam Tosetto Kieran Sheahan Diarmuid O’Donoghue Hugh Mulcahy Jacintha O’Sullivan |
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| Affiliation: | (1) Centre for Colorectal Disease, St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland;(2) University College Dublin, Dublin, Ireland; |
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| Abstract: | Background and Aims In vitro studies have shown that clusterin modulates treatment sensitivity in a number of human cancers; however, the interaction between clusterin expression and hypoxia in controlling treatment response in CRC has not previously been examined. The aim of this study was to assess the effect of clusterin overexpression in CRC cells on sensitivity to 5-fluorouracil (5-FU), oxaliplatin and FOLFOX treatment under normoxic and graded hypoxic conditions. |
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